Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adenosine A1 receptor |
| Gene Name | ADORA1 |
| Uniprot | P30542 (Human); Q60612 (Mouse) |
| Synonym | RDC7; adenosine A1 receptor variant 1; adenosine A1 receptor variant 2; AA1R |
| Background | The adenosine A1 receptor (ADORA1) belongs to the adenosine receptor group of G protein-coupled receptors which use adenosine as endogenous ligand. The A1 receptor includes A2A, A2B, and A3 and displays high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria. ADORA1 is encoded by the ADORA1 gene. An important paralog of this gene is ADORA2A. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX340 | NativeExtract™ Human ADORA1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| S01YF-0622-KX131 | MemDX™ Recombinant Human ADORA1 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cell | Full length | VLPs |
| MPX0888K | MemDX™ Membrane Protein Human ADORA1 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
R***n: Highly recommended for rigorous GPCR research.
04/Nov/2023
F**n: A trusted partner for complex projects.
26/Mar/2024
ADORA1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
Targeted Gene Editing for ADORA1-Mediated Neuromodulation
Creative Biolabs offers targeted gene editing services. Gene editing approaches enable precise genomic modifications at the ADORA1 locus, facilitating allele-specific correction or overexpression in preclinical models of neuropsychiatric disorders. For instance, single-guide RNA sequences optimized for ADORA1 promoter regions have been utilized to enhance transcriptional activity in rodent striatal neurons, effectively reversing apathy-like behaviors in chronic stress paradigms. Creative Biolabs' proprietary bioinformatics pipelines ensure RNA specificity, minimizing off-target effects critical for translational applications. These methodologies provide actionable insights into ADORA1's role in adenosine signaling dysregulation, positioning gene editing as a cornerstone for tailored neurological therapies.
AAV-Driven ADORA1 Gene Silencing in Chronic Pain Management
Creative Biolabs offers AAV-driven ADORA1 gene silencing services. Recombinant adeno-associated virus (AAV) vectors engineered with short hairpin RNA (shRNA) payloads permit spatially resolved ADORA1 knockdown in nociceptive pathways. Preclinical studies employing dorsal root ganglion (DRG)-targeted AAV9 serotypes demonstrate attenuated hyperalgesia in neuropathic pain models, correlating with reduced ADORA1 mRNA levels validated via qRT-PCR. Creative Biolabs' end-to-end vector design services include tissue-specific promoter selection and biodistribution profiling, ensuring optimal silencing efficacy. Such strategies highlight the therapeutic potential of modulating ADORA1 expression to disrupt aberrant purinergic signaling in chronic pain syndromes.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADORA1 cell therapy. Please for more services.
ADORA1-Expressing CAR-T Cells for Autoimmune Disorder Intervention
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells engineered to overexpress ADORA1 exhibit enhanced immunosuppressive capabilities through adenosine-mediated A2A receptor activation on effector T cells. In experimental autoimmune encephalomyelitis (EAE) models, these CAR-T constructs reduce CNS inflammation by converting pro-inflammatory microenvironments into anti-inflammatory niches. Creative Biolabs' modular CAR cassette development platform enables rapid iteration of co-stimulatory domains tailored to ADORA1 signaling dynamics, accelerating proof-of-concept validation. This approach exemplifies how cellular engineering can harness endogenous regulatory pathways for immune tolerance induction.
Stem Cell-Derived ADORA1+ Neural Progenitors for Ischemic Stroke Recovery
Creative Biolabs offers stem cell-derived ADORA1+ neural progenitors development services. Induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) transfected with ADORA1 agonists enhance neuroprotection in post-ischemic brain regions via adenosine-dependent suppression of glutamate excitotoxicity. Transplantation studies in murine stroke models reveal improved motor recovery and reduced infarct volumes, validated through longitudinal MRI and behavioral assays. Creative Biolabs' differentiation protocols ensure scalable production of ADORA1-enriched NPCs, addressing critical challenges in cell viability and phenotypic stability. These advancements underscore ADORA1's therapeutic versatility across regenerative medicine applications.
The intricacies of ADORA1-targeted gene and cell therapies demand precision-engineered solutions, from vector optimization to functional validation. Creative Biolabs' multidisciplinary team delivers end-to-end support, leveraging decades of experience in purinergic receptor biology and advanced genomic tools. to explore how our tailored platforms can accelerate your ADORA1 program from target discovery to IND-enabling studies. Harness the full potential of adenosine signaling modulation—partner with a leader in innovative therapeutic development.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
