Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adenosine A2b receptor |
| Gene Name | ADORA2B |
| Uniprot | P29275 (Human); Q60614 (Mouse) |
| Synonym | ADORA2; adenosine receptor A2b |
| Background | Adenosine receptor A2b (ADORA2B) is a protein that in human is encoded by the ADORA2B gene. ADORA2B is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A, and A3. The ADORA2B gene, which is located near the Smith-Magenis syndrome region on chromosome 17, encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein not only stimulates adenylate cyclase activity in the presence of adenosine but also interacts with netrin-1 that is involved in axon elongation. Among the related pathways of the protein, ADORA2B are Nucleotide-like (purinergic) receptors and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled adenosine receptor activity. An important paralog of this gene is ADORA2A. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX401 | NativeExtract™ Human ADORA2B Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3355K | MemDX™ Membrane Protein Human ADORA2B Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0019X | MemDX™ Membrane Protein Human ADORA2B (Adenosine A2b receptor) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
W***er: Reliable batch consistency, excellent solubility, and responsive technical support make it ideal for GPCR signaling studies.
03/Dec/2023
A**a: Customized N-terminal His-tag and biotinylation options performed flawlessly.
22/Jun/2024
ADORA2B Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
ADORA2B Promoter Editing
Creative Biolabs offers ADORA2B promoter editing services. ADORA2B, a G-protein-coupled receptor implicated in inflammatory and hypoxic responses, presents a compelling target for gene therapy. Precision-engineered single-guide RNAs targeting conserved regions of the ADORA2B promoter enable selective modulation of receptor expression. For instance, in preclinical models of pulmonary fibrosis, ADORA2B silencing attenuated pathological collagen deposition by disrupting adenosine-mediated fibroblast activation. Creative Biolabs' proprietary RNA optimization algorithms ensure minimal off-target effects while maximizing editing efficiency—an indispensable asset for translational applications.
AAV-Mediated ADORA2B Isoform Delivery
Creative Biolabs offers AAV-mediated ADORA2B isoform delivery services. Adeno-associated virus (AAV) vectors engineered with cell-specific tropism offer a sophisticated platform for ADORA2B isoform replacement. In cardiac ischemia models, intramyocardial delivery of AAV9 vectors carrying the ADORA2B long isoform enhanced angiogenesis by stabilizing hypoxia-inducible factor-1α (HIF-1α). Creative Biolabs' expertise in capsid pseudotyping ensures precise transduction of endothelial or epithelial cells, thereby maximizing therapeutic specificity. This approach is particularly salient for diseases characterized by ADORA2B dysfunction, such as chronic obstructive pulmonary disorder.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADORA2B cell therapy. Please for more services.
Chimeric Antigen Receptor (CAR) Macrophage Engineering
Creative Biolabs offers CAR macrophage engineering services. ADORA2B overexpression in tumor-associated macrophages (TAMs) drives immunosuppression in solid malignancies. CAR macrophages reprogrammed to express ADORA2B-blocking domains—such as dominant-negative receptor variants—selectively disrupt adenosine signaling within the tumor microenvironment. In glioblastoma xenografts, this strategy reduced interleukin-10 secretion by 68%, potentiating T-cell infiltration. Creative Biolabs' lentiviral transduction protocols, optimized for primary macrophage viability, ensure robust transgene expression without compromising phagocytic function.
iPSC-Derived ADORA2B Antagonists
Creative Biolabs offers iPSC-derived ADORA2B antagonist development services. Patient-derived iPSCs differentiated into ADORA2B-high epithelial cells enable high-throughput screening of receptor antagonists. For example, iPSC-based lung organoids exposed to hypoxia revealed ADORA2B-dependent NLRP3 inflammasome activation mediated by receptor knockdown. Creative Biolabs' end-to-end cell therapy development services, including clonal selection and 3D culture optimization, accelerate the identification of ADORA2B-modulating candidates.
Our two decades of expertise in adenosine receptor biology and advanced therapeutic delivery systems position us as the ideal collaborator for ADORA2B-focused projects. From RNA design to AAV vector manufacturing, Creative Biolabs delivers end-to-end solutions tailored to your preclinical and translational objectives. to schedule a technical consultation and leverage our proprietary tools for accelerating your ADORA2B drug development program.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
