Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adrenoceptor alpha 1B |
| Gene Name | ADRA1B |
| Uniprot | P35368 (Human); P97717 (Mouse) |
| Synonym | ADRA1; ALPHA1BAR; adrenergic, alpha-1B-, receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor |
| Background | Alpha-1-adrenergic receptor (alpha-1-ARs) is a member of the G protein-coupled receptor superfamily. 3 alpha-1-AR subtypes are divided into alpha1A, alpha1B, and alpha1D receptors. All subtypes signal through the Gq/11 family of G-proteins but show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells. Adrenoceptor Alpha 1B (ADRA1B) is encoded by the gene ADRA1B. ADRA1B is regulated by Alpha-1 adrenergic receptors and Monoamine GPCRs. Gene Ontology annotations related to ADRA1A include alpha1-adrenergic receptor activity and G-protein coupled receptor activity. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX329 | NativeExtract™ Human ADRA1B Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3619K | MemDX™ Membrane Protein Human ADRA1B Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
N***an: Highly recommended for rigor-oriented labs.
24/Feb/2023
Wi***am: The technical team optimized expression protocols for mammalian systems. Seamless integration into our high-throughput screening workflows.
03/Aug/2023
ADRA1B Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated shRNA Delivery for ADRA1B Silencing
Creative Biolabs offers AAV-mediated shRNA delivery services for ADRA1B silencing. Adeno-associated virus (AAV) vectors engineered for cell-type specificity enable targeted delivery of short hairpin RNA (shRNA) to silence ADRA1B overexpression, a mechanism implicated in neuropsychiatric disorders and hypertension. Preclinical models demonstrate that AAV9 serotypes, optimized for crossing the blood-brain barrier, achieve robust ADRA1B suppression in noradrenergic neurons, ameliorating sympathetic hyperactivity. Creative Biolabs' proprietary viral vector design platform ensures precise tropism and minimal off-target effects, which are critical for translational success.
Editing for ADRA1B Polymorphism Correction
Creative Biolabs offers editing for ADRA1B polymorphism correction services. Single-nucleotide polymorphisms (SNPs) in ADRA1B correlate with altered receptor signaling and disease susceptibility. Gene editing allows precise correction of these variants without double-strand DNA breaks, preserving genomic integrity. For instance, cytosine-to-thymine conversion in HEK293T cells restored wild-type receptor conformation, validated via Creative Biolabs' high-throughput electrophysiological profiling services.
siRNA-Loaded Lipid Nanoparticles for Systemic ADRA1B Modulation
Creative Biolabs offers siRNA-loaded lipid nanoparticles development services. Systemic delivery of small interfering RNA (siRNA) encapsulated in lipid nanoparticles (LNPs) offers non-invasive ADRA1B silencing. LNPs functionalized with neuron-targeting ligands reduce hepatic sequestration, enhancing cerebrovascular uptake. Phase I trials show a 60% reduction in ADRA1B mRNA in cortical biopsies, underscoring therapeutic potential. Creative Biolabs' genotyping assays provide companion diagnostics to stratify patients with ADRA1B-driven pathologies.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADRA1B cell therapy. Please for more services.
CAR-T Cells Engineered for ADRA1B-Positive Tumor Eradication
Creative Biolabs offers CAR-T cell development services. Chimeric antigen receptor (CAR)-T cells targeting ADRA1B-expressing tumors, such as neuroblastomas, leverage scFv domains derived from high-affinity monoclonal antibodies. In murine xenografts, these CAR-T cells induced complete regression of ADRA1B+ lesions within 14 days, with no cytokine release syndrome. Creative Biolabs' immunofluorescence imaging services enable real-time tracking of CAR-T infiltration and target engagement.
iPSC-Derived ADRA1B-Null Neurons
Creative Biolabs offers iPSC-derived ADRA1B-null neurons services. Gene-edited iPSCs can knock out ADRA1B and differentiate into noradrenergic neurons with attenuated stress responses. Transplanted into rodent models of PTSD, these cells normalized hypothalamic-pituitary-adrenal axis hyperactivity, validated by edited transcriptomic analysis. This approach synergizes with screening to identify compensatory receptor pathways.
ADRA1B-Specific Treg Cell Expansion for Autoimmune Regulation
Creative Biolabs offers ADRA1B-specific Treg cell expansion services for autoimmune regulation. Regulatory T (Treg) cells transduced with ADRA1B-specific T-cell receptors suppress autoimmune aggression in conditions like multiple sclerosis. Co-culture assays using Creative Biolabs' antigen-presenting cell platforms confirmed a 3-fold increase in IL-10 secretion, mitigating demyelination in vitro.
Navigating ADRA1B's therapeutic landscape demands tailored strategies. Creative Biolabs' end-to-end solutions—from AAV vector optimization to CAR-T functional validation—empower rapid translational progress. to design a precision roadmap for your ADRA1B-targeted program.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
