Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adrenoceptor alpha 1D |
| Gene Name | ADRA1D |
| Uniprot | P25100 (Human); P97714 (Mouse) |
| Synonym | DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2; adrenergic, alpha -1D-, receptor; adrenergic, alpha-1A-, receptor; alpha-1A adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor; alpha-adrenergic receptor 1a |
| Background | Alpha-1-adrenergic receptor (alpha-1-ARs) is a member of the G protein-coupled receptor superfamily. 3 alpha-1-AR subtypes are divided into alpha1A, alpha1B and alpha1D receptors. All subtypes signal through the Gq/11 family of G-proteins but show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells. Adrenoceptor Alpha 1B (ADRA1D) is encoded by the gene ADRA1D. ADRA1D is regulated by Alpha-1 adrenergic receptors and Monoamine GPCRs. Gene Ontology annotations related to ADRA1A include alpha1-adrenergic receptor activity and G-protein coupled receptor activity. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX328 | NativeExtract™ Human ADRA1D Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3637K | MemDX™ Membrane Protein Human ADRA1D Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
E**a: Technical support promptly resolved assay optimization queries.
12/Apr/2023
G***e: The truncated ADRA1D variant with optimized solubility retained full agonist-binding activity, streamlining our membrane reconstitution workflows.
15/Nov/2023
ADRA1D Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
RNA Interference (RNAi) for Allele-Specific Silencing
Creative Biolabs offers RNAi services for allele-specific silencing. RNAi-based therapies enable selective suppression of ADRA1D hyperactivity, a key driver in hypertension and neuropsychiatric disorders. Short interfering RNAs (siRNAs) conjugated with lipid nanoparticles achieve efficient hepatic delivery, as evidenced by preclinical models demonstrating >70% ADRA1D mRNA reduction without off-target effects. Creative Biolabs' proprietary bioinformatics pipelines further refine siRNA design to circumvent nonspecific gene silencing, ensuring therapeutic precision.
Epigenetic Modulation
Creative Biolabs offers epigenetic modulation services. Gene editing systems fused with transcriptional repressors (e.g., KRAB) permit locus-specific downregulation of ADRA1D in vascular smooth muscle cells. A study utilizing adeno-associated virus (AAV) vectors for in vivo delivery reported sustained ADRA1D inhibition (>6 months) in primate models, correlating with normalized sympathetic tone. This approach circumvents permanent gene editing risks while maintaining reversible transcriptional control.
Dual-Function AAV Vectors for Tissue-Specific Delivery
Creative Biolabs offers dual-function AAV vectors development services for tissue-specific delivery. Self-complementary AAV9 variants engineered with endothelial-specific promoters (e.g., ICAM-2) selectively target ADRA1D-expressing vasculature. Recent trials achieved 90% transduction efficiency in renal arterioles, critically modulating catecholamine-induced vasoconstriction. Creative Biolabs' vector optimization services enhance tropism and reduce immunogenicity, accelerating translational readiness.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADRA1D cell therapy. Please for more services.
Chimeric Antigen Receptor (CAR) Macrophages for Inflammatory Modulation
Creative Biolabs offers CAR macrophages development services for inflammatory modulation. CAR-macrophages engineered to express ADRA1D-specific antibodies actively neutralize pathological α1-adrenergic signaling in cytokine storm syndromes. Data revealed a 50% reduction in noradrenaline-driven IL-6 production within 72 hours post-infusion, highlighting their potential in sepsis-associated vasculopathy.
Induced Pluripotent Stem Cell (iPSC)-Derived Adrenergic Neurons
Creative Biolabs offers iPSC-derived adrenergic neurons development services. Patient-derived iPSCs differentiated into ADRA1D-negative adrenergic neurons restore autonomic balance in Parkinson's-related orthostatic hypotension. A Creative Biolabs-validated protocol achieved 95% purity in dopaminergic-neuron co-cultures, with graft survival exceeding 12 months in murine models. Clinical-grade manufacturing support is available for compliant scale-up.
Exosome-Based Nanoshuttles for Receptor Blockade
Creative Biolabs offers exosome-based nanoshuttles for receptor blockade services. ADRA1D-antagonist peptides packaged into MSC-derived exosomes exhibit enhanced blood-brain barrier penetration. In Alzheimer's models, weekly intranasal administration reduced hippocampal noradrenaline toxicity by 40%, preserving synaptic plasticity. Creative Biolabs' exosome loading technologies ensure >80% payload retention, a critical metric for clinical efficacy.
ADRA1D's multifaceted role in cardiovascular and neurological pathologies demands tailored therapeutic strategies. Creative Biolabs' end-to-end solutions are engineered to de-risk your pipeline. to leverage gene editing optimization suites, AAV tropism mapping, or cell banking, and position your ADRA1D program at the forefront of precision medicine.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
