Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adrenoceptor beta 1 |
| Gene Name | ADRB1 |
| Uniprot | P08588 (Human); P34971 (Mouse) |
| Synonym | adrenergic, beta-1-, receptor; beta-1 adrenoceptor; beta-1 adrenoreceptorRHR; B1AR; FNSS2; ADRB1R; BETA1AR |
| Background | ADRB1 membrane protein belongs to the beta receptors of the adrenergic receptor family (alpha 1, alpha 2, beta 1, and beta 2), which is responsible for mediating the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. The beta 1 adrenergic receptor (ADRB1) is encoded by an intronless gene located on chromosome 10q24-26. It is coupled to the Gs G-protein/adenyl cyclase signal transduction pathway, a central pathway to regulating cardiac function. It has been demonstrated to be equally sensitive to epinephrine and norepinephrine. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-0622-KX108 | MemDX™ Recombinant Human ADRB1 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cell | Full length | VLPs |
| MPX0905K | MemDX™ Membrane Protein Human ADRB1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MPX4399K | MemDX™ Membrane Protein Human ADRB1 Expressed in Yeast with 6xHis tag at the N-terminus, Partial (378-477aa) | Yeast cell | Partial | N/A |
| Please for more products or customization | ||||
Fo***st: Technical support for GPCR-specific protocols was highly responsive and solution-driven.
11/Apr/2023
J***er: Tailored ADRB1 variants delivered within 4 weeks.
25/Jan/2024
ADRB1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated ADRB1 Gene Delivery
Creative Biolabs offers AAV-mediated ADRB1 gene delivery services. Adeno-associated virus (AAV) vectors enable tissue-specific delivery of ADRB1-targeted genetic constructs, such as wild-type ADRB1 for receptor upregulation in cardiac failure models. Preclinical studies demonstrate that AAV9 serotypes achieve robust myocardial transduction, restoring β1-adrenergic receptor density and improving contractility in cardiomyopathy. Creative Biolabs' viral vector engineering platform enhances tropism for cardiomyocytes, ensuring precise targeting of ADRB1-expressing cells.
Gene Editing for ADRB1 Variant Correction
Creative Biolabs offers gene editing services for ADRB1 variant correction. Single-nucleotide polymorphisms (SNPs) in ADRB1 correlate with altered receptor signaling and drug response variability. Gene editing systems allow allele-specific editing to correct pathogenic mutations or modulate receptor activity. For instance, base-editing tools have been employed to revert hyperactive Arg389 alleles to Gly389 in in vitro cardiomyocyte models, normalizing catecholamine responsiveness.
RNA Interference for ADRB1 Silencing
Creative Biolabs offers RNA interference services. Antisense oligonucleotides (ASOs) targeting ADRB1 mRNA reduce receptor overexpression in hyperadrenergic states. Lipid nanoparticle-encapsulated ASOs selectively downregulate ADRB1 in sympathetic neurons, attenuating pathological cardiac remodeling in hypertension models. Creative Biolabs' gene expression profiling services validate knockdown efficiency and off-target effects, ensuring therapeutic specificity.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADRB1 cell therapy. Please for more services.
CAR-T Cell Engineering for ADRB1+ Tumor Targeting
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR) T cells targeting ADRB1-positive tumors are under investigation for neuroendocrine carcinomas. Preclinical CAR constructs fused with β1-adrenergic receptor ligands exhibit precise recognition of ADRB1-overexpressing cells, inducing apoptosis in vitro. Creative Biolabs' immunofluorescence assays enable high-resolution validation of CAR-T cell binding specificity and cytotoxicity in 3D tumor spheroids.
Stem Cell-Derived Cardiomyocytes with Modified ADRB1 Signaling
Creative Biolabs offers stem cell-derived cardiomyocyte development services. Induced pluripotent stem cell (iPSC)-derived cardiomyocytes engineered with constitutively active ADRB1 variants serve as disease models for drug screening. These cells replicate hypertrophic phenotypes, enabling the evaluation of β-blocker efficacy. Creative Biolabs' imaging techniques, including confocal microscopy, quantify intracellular calcium dynamics to assess therapeutic modulation of ADRB1 activity.
Viral Vector-Transduced Autologous Cells
Creative Biolabs offers viral vector-transduced autologous cells development services. Ex vivo transduction of patient-derived fibroblasts with ADRB1-encoding lentiviral vectors generates bioengineered cell implants for myocardial regeneration. Implanted cells secrete ADRB1 agonists, enhancing local adrenergic signaling in ischemic zones. Creative Biolabs' genotyping services ensure patient-specific compatibility, minimizing immune rejection risks.
Creative Biolabs' integrated platforms—spanning viral vector design, gene editing validation, and high-content cellular imaging—provide end-to-end support for ADRB1 therapeutic development. to explore tailored solutions for your gene or cell therapy pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
