Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adrenoceptor beta 2 |
| Gene Name | ADRB2 |
| Uniprot | P07550 (Human); P18762 (Mouse) |
| Synonym | BAR; B2AR; ADRBR; ADRB2R; BETA2AR; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor |
| Background | The β2-adrenergic receptor (β2AR, ADRB2) is a prototypic G-protein coupled receptor (GPCR). Like all GPCRs, the ADRB2 has seven transmembrane-spanning segments. This receptor is involved in the production of physiological responses to adrenaline and noradrenaline. Upon binding to specific agonists, several signaling pathways can be triggered. It is reported to couple predominantly with stimulatory Gαs and to a lesser extent with inhibitory Gαi to modulate the activity of adenylyl cyclase and mitogen-activated protein kinases (MAPKs). Besides, proteins can directly interact with ADRB2 to produce physiologically relevant outcomes in a G protein-independent manner. ADRB2 is widely expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX324 | NativeExtract™ Human ADRB2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MP1326J | MemDX™ Membrane Protein Human ADRB2 (Adrenoceptor beta 2) for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| MP0022X | MemDX™ Membrane Protein Human ADRB2 (Adrenoceptor beta 2) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0021X | MemDX™ Membrane Protein Human ADRB2 (Adrenoceptor beta 2) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
O***n: Exceptional quality and bioactivity consistency.
05/Aug/2023
E*r: Customizable formats delivered promptly.
09/Mar/2024
ADRB2 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
ADRB2 Mutation Correction
Creative Biolabs offers ADRB2 mutation correction services. Gene editing systems enable precise editing of gain-of-function ADRB2 mutations, such as the Thr164Ile polymorphism linked to receptor overactivation in asthma and cardiovascular disorders. By delivering RNA ribonucleoprotein complexes via lipid nanoparticles, somatic cells can be transiently transfected to excise hyperactive alleles while preserving wild-type receptor function. Creative Biolabs' proprietary off-target minimization algorithms ensure high specificity for clinical translation.
AAV-Delivered ADRB2 Wild-Type Gene Replacement
Creative Biolabs offers AAV-delivered ADRB2 wild-type gene replacement services. Adeno-associated virus (AAV) vectors engineered with cardiac- or lung-tropic capsids selectively deliver wild-type ADRB2 transgenes to restore β2-adrenergic receptor density in tissues with loss-of-function variants. Preclinical studies demonstrate sustained receptor expression (>6 months) in cardiomyocytes and bronchial epithelial cells, rescuing cAMP signaling pathways disrupted by Gly16Arg polymorphisms. Creative Biolabs' capsid optimization platform enhances tropism specificity for therapeutic payload delivery.
siRNA Silencing of Constitutively Active ADRB2 Mutants
Creative Biolabs offers siRNA silencing of constitutively active ADRB2 mutants services. Small interfering RNA (siRNA) duplexes targeting ADRB2 mRNA regions harboring activating mutations (e.g., Glu27Gln) suppress pathological receptor overactivity. Lipid-conjugated siRNAs achieve >90% knockdown in airway smooth muscle cells, mitigating bronchoconstriction in COPD models. Creative Biolabs' custom nucleotide modifications extend siRNA serum stability, enabling biweekly dosing regimens.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADRB2 cell therapy. Please for more services.
CAR-T Cell Modulation of ADRB2-Driven Fibrosis
Creative Biolabs offers CAR-T cell modulation of ADRB2-driven fibrosis services. Chimeric antigen receptor (CAR)-T cells engineered to recognize ADRB2-overexpressing fibroblasts degrade fibrotic matrices via MMP-9 secretion, addressing pulmonary and cardiac fibrosis. In vivo models show 40% reduction in collagen deposition post-infusion. Creative Biolabs' lentiviral transduction protocols optimize CAR expression without T-cell exhaustion.
Stem Cell-Derived β2-AR-High Progenitors
Creative Biolabs offers stem cell-derived β2-AR-high progenitors development services. Induced pluripotent stem cells (iPSCs) differentiated into ADRB2-overexpressing cardiomyocyte progenitors enhance contractility in heart failure models. These cells exhibit 3-fold higher β2-AR density than native cardiomyocytes, improving responsiveness to endogenous catecholamines. Creative Biolabs' GMP-compliant differentiation kits standardize progenitor cell yields for scalable production.
Monoclonal Antibody-Armed Macrophages
Creative Biolabs offers monoclonal antibody-armed macrophages development services. Macrophages transfected with anti-ADRB2 monoclonal antibodies (e.g., IgG1 clones) selectively clear receptor aggregates in neurodegenerative models. Antibody-Fc receptor interactions amplify phagocytic activity, reducing intracellular β2-AR inclusion bodies by 70% in glial cells. Creative Biolabs' hybridoma development services accelerate antibody validation for adoptive cell therapies.
Creative Biolabs' integrated platforms—from gene editing design to AAV manufacturing—provide end-to-end solutions for ADRB2-targeted drug development. to explore tailored strategies for your gene or cell therapy program.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
