Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Angiotensin II receptor type 1 |
| Gene Name | AGTR1 |
| Uniprot | P30556 (Human); P29754 (Mouse) |
| Synonym | AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B; type-1B angiotensin II receptor |
| Background | AGTR1 or AT1 is a classic seven-transmembrane domain G-protein coupled receptor (GPCR). It is the most frequently studied and best-characterized angiotensin receptor. It activates a classical Gq/11 protein and phospholipase C pathway to produce second messengers, such as inositol trisphosphate and diacylglycerol, leading to the intracellular calcium flux and activation of protein kinases including the extracellular regulated kinases, ERK1/2. In murine species, the AT1 receptor is subdivided into AT1A and AT1B subtypes, while in other mammalian species, including human, this subdivision does not exist. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX396 | NativeExtract™ Human AGTR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MP0026X | MemDX™ Membrane Protein Human AGTR1 (Angiotensin II receptor type 1) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX635 | MemDX™ Membrane Protein Human AGTR1 (1-27aa) Expressed in HEK293, C-Human Fc tag | HEK293 cell | Partial | N/A |
| MPX4346K | MemDX™ Membrane Protein Human AGTR1 Expressed in Yeast with 6xHis tag at the N-terminus, Partial (297-359aa) | Yeast cell | Partial | N/A |
| Please for more products or customization | ||||
With our advanced cell line construction platform and extensive experience, we offer you high-quality and highly stable membrane protein stable cell lines to support your research and drug development.
| CAT# | Product Name | Target Species | Host Cell |
| S01YF-1022-KX203 | MemDX™ Human FLAG tagged AGTR1 HEK293T Cell Line, Calcium flux assay | Human | HEK293T |
| S01YF-1022-KX23 | MemDX™ Human AGTR1 HEK293 Cell Line, Calcium flux assay | Human | HEK293T |
| Please contact us for more products or customization | |||
S***n: The tailored extracellular domain variant demonstrated robust activity in GPCR signaling assays.
13/Mar/2023
E*: Ideal for high-throughput screening setups.
26/Oct/2023
AGTR1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AGTR1 Silencing for Hypertension Management
Creative Biolabs offers AGTR1 silencing services for hypertension management. Gene-editing technologies enable precise disruption of AGTR1, a critical regulator of blood pressure via the renin-angiotensin system. For instance, viral vectors engineered to deliver guide RNAs targeting AGTR1 exons have demonstrated sustained receptor suppression in preclinical models, reducing angiotensin II-induced vasoconstriction. Creative Biolabs' expertise in vector optimization ensures high specificity and minimal off-target effects, supporting translational studies for resistant hypertension.
AAV-Delivered Dominant-Negative AGTR1 Constructs for Cardiovascular Remodeling
Creative Biolabs offers AAV-delivered dominant-negative AGTR1 constructs services for cardiovascular remodeling. Adeno-associated viruses (AAV) can deliver dominant-negative AGTR1 mutants to attenuate pathological signaling in cardiac fibroblasts. This approach mitigates maladaptive hypertrophy and fibrosis in animal models of heart failure. Coupled with Creative Biolabs' cell-specific promoter engineering, such vectors achieve tissue-restricted expression, minimizing systemic side effects.
Creative Biolabs offers comprehensive and innovative services to drive the development of AGTR1 cell therapy. Please for more services.
CAR-T Cell Engineering for AGTR1-Overexpressing Solid Tumors
Creative Biolabs offers CAR-T cell engineering services for AGTR1-overexpressing solid tumors. Chimeric antigen receptor (CAR) T cells targeting AGTR1 show promise in cancers where receptor overexpression drives proliferation, such as certain breast carcinomas. Creative Biolabs' immunofluorescence platforms validate AGTR1 surface localization in tumor biopsies, enabling the design of high-affinity CAR constructs. Preclinical data reveal targeted cytotoxicity against AGTR1+ cells while sparing healthy tissues.
AGTR1-Antagonizing Mesenchymal Stem Cells (MSCs) for Fibrotic Disorders
Creative Biolabs offers AGTR1-antagonizing MSCs development services. MSCs engineered to secrete AGTR1-blocking peptides or antibodies locally disrupt profibrotic signaling in renal or pulmonary microenvironments. Creative Biolabs' gene expression profiling services ensure robust transgene validation and safety assessment, accelerating IND-enabling studies.
From silencing to cell-specific viral vectors, AGTR1-targeted therapies demand precision tools and deep domain knowledge. Creative Biolabs' end-to-end solutions—spanning antibody validation, vector design, and preclinical models—empower innovators to accelerate breakthroughs. to refine your AGTR1 program's strategy.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
