AGTR2 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of AGTR2

Protein Name	Angiotensin II receptor type 2
Gene Name	AGTR2
Uniprot	P50052 (Human); P35374 (Mouse)
Synonym	AT2; ATGR2; MRX88; angiotensin II type-2 receptor
Background	AGTR2, also known as AT2, is an angiotensin II receptor and it is an integral membrane protein belonging to the G protein-coupled receptor (GPCR) family. The cDNA for AGTR2 encodes a 363-amino acid protein, with a molecular weight of 41220 Da. This receptor shares only ~34% sequence homology with the AT1 receptor. The gene for AGTR2 resides on the X-chromosome and has 3 exons with the entire coding region on the third exon. With respect to G-protein coupling, studies have suggested that AGTR2 may be coupled to G-proteins and that the third intracellular loop may be linked with the cell signaling pathway involving Gi and extracellular signal-regulated kinases (ERK) inactivation.

AGTR2 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX301	NativeExtract™ Human AGTR2 Membrane Protein (Full length, Super Nanodisc)	HEK293 cell	Full length	Native Nanodisc
MPX4590K	MemDX™ Membrane Protein Human AGTR2 Expressed in E.coli with 6xHis and SUMO tag at the N-terminus, Partial (1-45aa)	E.coli cell	Partial	N/A
MP1327J	MemDX™ Membrane Protein Rat Agtr2 (Angiotensin II receptor, type 2) for Antibody Discovery	E.coli cell	Partial	N/A
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Customer Reviews

T***ia: Ideal for high-sensitivity assays and reproducible ligand-binding studies.

06/May/2023

K***n: AGTR2 lyophilized formulations maintain stable activity post-reconstitution, even after long-term storage.

14/Dec/2023

Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

AGTR2 Drug Discovery and Development

AGTR2 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-AGTR2 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

AGTR2 Gene Therapy Development

We provide tailored solutions to meet your specific requirements. Please inquire us for more services.

Allelic Correction

Creative Biolabs offers allelic correction services. Precision genome editing via gene editing enables site-specific modulation of AGTR2-associated pathogenic variants. For instance, single-guide RNA designed against hyperactive AGTR2 alleles linked to hypertension has demonstrated >85% editing efficiency in preclinical cardiomyocyte models, restoring calcium signaling homeostasis. Creative Biolabs' gene editing optimization platform ensures minimal off-target effects through proprietary algorithms, making this approach viable for hereditary cardiovascular disorders.

AAV-Delivered shRNA Silencing

Creative Biolabs offers AAV-delivered shRNA silencing services. Recombinant adeno-associated virus (AAV) vectors engineered to deliver short hairpin RNA (shRNA) achieve sustained AGTR2 knockdown in vivo. A recent study showed that intrarenal AAV9-shRNA administration reduced AGTR2 mRNA by 72% in diabetic nephropathy models, attenuating fibrosis and albuminuria. Creative Biolabs' AAV serotype screening services identify tissue-specific capsids for optimal delivery.

Epigenetic Modulation via Lentiviral Constructs

Creative Biolabs offers epigenetic modulation via lentiviral constructs services. Lentiviral vectors encoding transcriptional activators upregulate AGTR2 expression in cancers where its tumor-suppressive role is compromised. In prostate adenocarcinoma xenografts, this strategy suppressed metastatic spread by 40% through reactivation of AGTR2-mediated apoptosis pathways.

AGTR2 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of AGTR2 cell therapy. Please inquire with us for more services.

Chimeric Antigen Receptor (CAR) Macrophage Engineering

Creative Biolabs offers CAR macrophage engineering services. AGTR2-specific CAR macrophages engineered to overexpress anti-inflammatory cytokines selectively infiltrate atherosclerotic plaques. In ApoE−/− mice, these cells reduced plaque volume by 58% via AGTR2-dependent efferocytosis enhancement, highlighting their potential for vascular inflammation management. Creative Biolabs' macrophage differentiation protocols ensure >90% functional maturation.

AGTR2-Edited iPSC-Derived Cardiomyocytes

Creative Biolabs offers AGTR2-edited iPSC-derived cardiomyocytes development services. Induced pluripotent stem cells (iPSCs) with gene-edited AGTR2 variants model patient-specific cardiac arrhythmias. Pharmacological testing on these cells identified four repurposed compounds that normalized irregular contractions by modulating AGTR2-calcium channel crosstalk. Our GMP-compliant iPSC banking ensures scalability for high-throughput drug screens.

Tissue-Specific NK Cell Recruitment

Creative Biolabs offers tissue-specific NK cell recruitment services. AGTR2-targeting bispecific antibodies redirect natural killer (NK) cells to eliminate AGTR2-overexpressing ovarian cancer cells. In PDX models, this approach improved survival rates by 3.2-fold compared to checkpoint inhibitors alone. Creative Biolabs' antibody humanization services enhance clinical translatability.

Leverage Creative Biolabs' end-to-end cell therapy expertise to accelerate your AGTR2 program from bench to clinic. Contact us to refine your AGTR2 therapeutic strategy with industry-leading genomic and cellular engineering solutions.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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