Amiloride-Sensitive Sodium Channel Family

Amiloride-sensitive sodium channel, also known as epithelial sodium channel (ENaC), is a membrane-bound ion channel which is composed of three homologous subunits (α, β, and γ). As a constitutively active channel, ENaC allows the flow of Na ions from the lumen into the epithelial cell, across the apical cell membrane. The absorbed Na ions are then pumped out of the cell into the interstitial fluid by the action of Na/K ATPase located on the basolateral membrane. It has been reported that the activity of ENaC is regulated by the renin-angiotensin-aldosterone system and a complex variety of extracellular factors including Na, Cl, protons, shear stress, and proteases. Until now, four members of the ENaC family have been identified, namely alpha-NaCH, beta-NaCH, delta-NaCH, and gamma-ENaC. Studies have shown that ENaC is involved primarily in the reabsorption of sodium ions at the collecting ducts of the kidney's nephrons. In addition, it also has a central role in the regulation of extracellular fluid volume and blood pressure.

Here, we have described in detail of members of the amiloride-sensitive sodium channel, including alpha-NaCH, beta-NaCH, delta-NaCH, and gamma-ENaC. To learn more detailed information, please click the links below.

Human ENaC Family Members

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