Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe anaphylatoxins C3a and C5a play important roles as mediators of inflammation and they regulate and control multiple innate and adaptive immune responses. The effector and regulatory functions of these anaphylatoxins are mediated through binding and activation of their cognate G protein-coupled receptors, including C3a receptor (C3aR), C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2). C3aR is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a and it stimulates chemotaxis, granule enzyme release, and superoxide anion production. C5aR1 is the receptor for anaphylatoxin C5a while C5aR2 is the receptor for C3a, C4a, and C5a. The activation of C5aR1 stimulates chemotaxis, granule enzyme release, intracellular calcium release, and superoxide anion production. C5aR2 is a modulator of C5AR1 signaling, exerting either anti- or pro-inflammatory activities.
Based on their pleiotropic functions, these anaphylatoxin receptors contribute not only to tissue homeostasis but drive, perpetuate and resolve immune responses in many inflammatory diseases including infections, malignancies, autoimmune as well as allergic diseases. Due to their contribution to different diseases, these receptors represent attractive drug targets and there is great promise for the development of anaphylatoxin receptor-targeted therapeutics in the future. Here, we give an introduction to the human anaphylatoxin chemotactic receptor members about their structure, regulation, biological roles, implications in disease states, and drug discovery.
To study membrane proteins in vitro, they have to be isolated from the natural membrane environments firstly and then incorporated into membrane mimetics that can retain the protein structure and stability. To do this, Creative Biolabs offers various strategies and methods to obtain your targets in solution. Our powerful Magic™ membrane protein production platform offers both detergent-aided and detergent-free approaches to reconstitute your target of interest in detergent micelles, proteoliposomes, nanodiscs, lipoparticles, or polymers.
These proteins can be prepared for different specific requirements and applications. Particularly, Creative Biolabs can develop antibodies against these proteins using our advanced antibody development technologies. If you want to learn more, please see Magic™ membrane protein antibody discovery. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in our services, please feel free to contact us for a discussion about your project purposes.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
