Introduction of ANO1
ANO1 (Anoctamin-1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-sensitive calcium-activated chloride channel that is expressed in smooth muscle and epithelial cells. In addition, it is highly expressed in human interstitial cells of Cajal (ICC) throughout the gastrointestinal tract. Changes in ANO1 channel activity is directly/positively correlated with ICC activity.
|Basic Information of ANO1|
|Aliases||DOG1, ORAOV2, TAOS2, TMEM16A|
|Organism||Homo sapiens (Human)|
Function of ANO1 Membrane Protein
ANO1 (Anoctamin-1), is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is documented that the changes of ANO1 activity are directly/positively correlated with interstitial cells of Cajal (ICC) activity. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Furthermore, ANO1 acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Fig.1 Structure-Function of ANO1/TMEM16A. (Pedemonte, 2014)
Application of ANO1 Membrane Protein in Literature
Anoctamin 1 (ANO1/TMEM16A) was identified as the major Ca2+-activated Cl- channel in airway epithelial cells, and the article demonstrated that downregulation of the anoctamin 1 channel in cystic fibrosis patients contributed to disease severity via an unknown mechanism. The authors showed that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improved mucus dynamics in mouse models.
This article implicated that TMEM16A can be regarded as a contributor to tumor progression by limiting apoptosis and as a potential biomarker of more aggressive disease.
This study indicated that Anoctamin 1 (TMEM16A) was essential for testosterone-induced prostate hyperplasia.
This article concluded that ANO1 was essential for the development of prostate hyperplasia and was a potential target for the treatment of BPH.
This article discussed the physiological implications of Ca2+-dependent phospholipid scrambling, the extracellular vesicles associated with this activity, and the roles of ANOs in these processes.
ANO1 Preparation Options
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