Introduction of ANO2
ANO2 (Anoctamin-2), also known as Transmembrane member 16B (TMEM16B), is a protein that, in humans, is encoded by the ANO2 gene. It functions as Ca2+-activated Cl− channels (CaCCs), a type of ion channel that plays important functions such as transepithelial ion transport, smooth muscle contraction, olfaction, phototransduction, nociception, and control of neuronal excitability.
|Basic Information of ANO2|
|Organism||Homo sapiens (Human)|
Function of ANO2 Membrane Protein
As a calcium-activated chloride channel, ANO2 may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells. ANO2 seems to be the underlying chloride channel involved in this process. In addition, ANO2 may mediate light perception amplification in the retina. It’s also identified as an autoimmune target found in multiple sclerosis. Furthermore, ANO2 has been identified as an autoimmune target in multiple sclerosis (MS) and the pathogenic role of ANO2 autoantibodies in MS has been revealed.
Fig.1 TMEM16A and TMEM16B function in neurons. (Pedemonte, 2014)
Application of ANO2 Membrane Protein in Literature
This article discusses the physiological implications of Ca2+-dependent phospholipid scrambling, the extracellular vesicles associated with this activity, and the roles of ANOs in these processes.
This article demonstrates that an ANO2 autoimmune subphenotype may exist in MS and lay the groundwork for further studies focusing on the pathogenic role of ANO2 autoantibodies in MS.
This study suggests that dual function is an ancestral characteristic of TMEM16 proteins and that some members, such as TMEM16A and TMEM16B/ANO2, have evolved to a pure channel function.
This article proposes that ANO2 constitutes the olfactory calcium-activated chloride channel.
This article demonstrates that anoctamins are a family of Ca(2+)-activated Cl(-) channels, which also induce permeability for cations. They may operate as Cl(-) channels located in the plasma membrane or in intracellular compartments.
ANO2 Preparation Options
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