Introduction of ANO7
ANO7 is encoded by the ANO7 gene. It is also known as TMEM16G and is a member of transmembrane protein 16 (TMEM16) family, which is responsible for a variety of physiological functions, such as ion transport, phospholipid scrambling and regulating other ion channels. The crystal structure of ANO7 has not been solved so far. The proposed structural model according to the amino acid sequence indicates that ANO7 possesses eight predicted transmembrane helices. Meanwhile, ANO7 is also known as Dresden-transmembrane protein of the prostate (D-TMPP).
|Basic Information of ANO7|
|Aliases||Dresden transmembrane protein of the prostate, D-TMPP, IPCA-5, Prostate cancer-associated protein 5, Transmembrane protein 16G, TMEM16G|
|Organism||Homo sapiens (Human)|
Function of ANO7 Membrane Protein
ANO7 is expressed in many different cell types, including epithelia and neurons. ANO7 functions as ion channels like the majority of TMEM16 proteins. It is involved in epithelial Cl- transport, smooth muscle contraction and neuronal signal processing. ANO7 is reported to conduct Cl- influx or Cl- efflux, and the balance is regulated by the dynamic system of intracellular chloride, which is decided by the various Cl-/cation co-transporters and their regulatory proteins. Moreover, ANO7 can work as lipid scramblases and catalyze the diffusion of lipids between the two leaflets of a bilayer. Even though the activity of TMEM16 has been implemented in a number of diseases including hypertension, asthma, diarrhoea, cancer and more recently ischaemia-induced arrhythmia, there is no non-selective nature of the pharmacology surrounding TMEM16 has impeded our knowledge of these proteins.
Fig.1 Proposed structure of ANO7 membrane protein (Brunner, 2014).
Application of ANO7 Membrane Protein in Literature
This article reveals the general architecture of the TMEM16 family and its mode of Ca2+ activation. It serves as a framework to unravel the conduction of ions in certain TMEM16 proteins.
The article reports that some mutations in anoctamin genes (ANO3, ANO5, ANO6, ANO7 and ANO10) result in various genetic diseases and suggests the involvement of anoctamins in a variety of cell functions whose link with ion transport and/or lipid scrambling.
The authors in this article apply the bioinformatic method to characterize the human ANO7 gene, which is consisted of 25 exons and located at human chromosome 2q37.3.
This article reveals that the mRNA of ANO7 encodes a putative multiple transmembrane protein of 883 amino acids and is selectively overexpressed in prostate tissue.
This article reviews the unknown structure and confusing functions of the TMEM16 family of membrane proteins and the links between TMEM16 functions and human physiology and pathologies need to be investigated.
ANO7 Preparation Options
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