Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAnoctamin (ANO), also known as transmembrane member 16 (TMEM16), is a class of transport proteins, detected in all eukaryotes. There are 10 members of anoctamin family in vertebrates (ANO1-10). The anoctamin proteins are highly hydrophobic and possess a similar structure with eight transmembrane domains, and one re-entry loop that consists of the NH2 and COOH termini protruding into the cytosol. They exert an essential role in ion transport. ANO1 and ANO2 function as Ca2+-activated Cl- channels (CaCCs) in many tissues, involved in transmembrane ion transport, smooth muscle contraction, olfaction, phototransduction, nociception, and control of neuronal excitability. Besides, other members of anoctamin family may be involved in phospholipid scrambling and/or ion channels. Studies have been indicated that ANO6 and ANO7 can produce chloride currents, and ANO6 may be a major regulator for phosphatidylserine translocation from the inner to the outer leaflet of the plasma membrane. Mutations in anoctamin genes may be associated with genetic diseases, such as cancer, cervical dystonia, gnathodyaphyseal dysplasia, Scott syndrome, cerebellar ataxia.
Among these 10 anoctamin proteins, ANO1 and ANO2 have been studied extensively so far. However, the studies of other members of anoctamin family are relatively lacking and their biological roles have not been elucidated completely. The following table shows the detailed descriptions of 10 anoctamin proteins.
Aided by cutting-edge MemDX™ membrane protein production platform, detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
