Creative Biolabs is a leading service provider that focuses on antibody engineering for research, diagnostic and therapeutic use. With extensive experience in antibody development, our scientists are able to provide superior engineering services about anti-glycan antibodies.
Antibodies are a group of glycoproteins naturally produced by the immune system with activities of defense against a variety of external and internal antigens, which has been widely applied in the clinic including the prevention, diagnosis, and treatment of diseases. The advent of the hybridoma technology by Köhler and Milstein in 1975 made it possible to produce identical monoclonal antibodies on a large scale. And with the development of the recent antibody-production techniques and platforms, the production and utilization of antibodies against target antigens of infectious pathogens, and malignant diseases enters a new era. During the past decade, the engineered antibody has become a major class of new drugs to treat cancers and autoimmune diseases. Therefore, novel engineering techniques and methods are necessary to optimize the antibodies or antibody-related molecules to improve specificity, affinity, functionality and so forth.
Fig.1 Illustration showing the production route of hybridoma technology (Saeed, 2017).
Anti-glycan antibodies are a class of special antibodies with specific reaction with carbohydrate-based antigens, which are essential for basic research and clinical therapy. As with other antibodies, desired anti-glycan antibodies can be specifically engineered or modified for a variety of purposes, such as affinity maturation, humanization, and half-life extension. The engineered anti-glycan antibodies are possible to be different isotypes and formats, which are usually constructed by a series of modern molecular biology techniques and methods, including hybridomas, genetic engineering techniques, phage display, construction of antibody fragments, and cell-free systems. For better performance, different modified anti-glycan antibodies products by corresponding strategies and techniques should be chosen to suit different applications.
Creative Biolabs is a well-recognized expert who devoted to the field of antibody engineering for over a decade. Our professional teams are fully confident in providing the most extensive and satisfying services about anti-glycan antibodies including applications, products, and related supports, since we possess absolute advantages which including but not limited to:
Just contact us and chose us! Our scientists are confident in offering satisfying and the best answers and services to promote your research or projects.
Reference:
