Custom Anti-GT1b Antibody Service for Neurological Autoimmunity Studies
Introduction to GT1b & Anti-GT1b Antibodies
GT1b is a sialic-acid–containing glycosphingolipid found in neuronal membranes. As a member of the b-series gangliosides, GT1b helps define membrane identity and nano-domain organization, providing biologically meaningful epitopes for immune recognition. In research settings, highly specific anti-ganglioside antibodies to GT1b enable you to:
- Map glycan-focused immune responses in neurological models.
- Differentiate GT1b from closely related gangliosides during specificity studies.
- Profile antibody binding across membrane mimetics (liposomes, supported bilayers).
- Quantify and visualize GT1b-dependent phenomena with robust, validated assays.
Creative Biolabs provides an end-to-end custom anti-ganglioside antibody service dedicated to generating high-quality anti-ganglioside antibodies with precise specificity to GT1b ganglioside. Built by senior scientists with decades of experience in glycan immunology and membrane biochemistry, our platform integrates rational antigen design for glycolipids, multi-modal discovery platforms, glycan-focused screening, and rigorous QC. We are committed to offering reproducible anti-GT1b antibody candidates you can trust for neurological autoimmunity research. Off-the-shelf anti-GT1b antibodies made for ELISA, IF, IHC, and WB are also provided if you require a fast start.
Custom Antibody Service Highlights
Creative Biolabs provides excellent custom anti-GT1b antibody development services. Our comprehensive platform is developed on the pillars of flexibility, specificity, and quality to help you speed your neurological autoimmunity research.
- Three complementary discovery routes (phage display, hybridoma, single-B-cell) to match your timeline, species, and format needs.
- Glycan-aware screening funnels, including competitive binding and glycoarray profiling against a broad panel (e.g., GM1, GM2, GM3, GD1a, GD1b, GD3, GT1a, GT1b).
- Format engineering for downstream use (IgG, Fab, scFv, sdAb; unlabeled or labelled).
- Clear, well-annotated reports suitable for audits and knowledge transfer.
Our Custom Anti-GT1b Antibody Service
Generating a truly specific anti-GT1b antibody presents a significant technical hurdle for many research teams. The intricate sugar structure of the GT1b ganglioside makes it a challenging antigen, and ensuring the final antibody doesn't cross-react with other closely related gangliosides demands a specialized approach. A lack of specificity can lead to ambiguous data, compromising the integrity of your neurological autoimmunity studies. At Creative Biolabs, we offer a fully integrated, step-by-step custom antibody service specifically designed to generate high-affinity, selective antibodies against GT1b ganglioside. Each project is tailored to your experimental goals, with multiple platforms and assay formats available to ensure optimal results in terms of specificity, reproducibility, and downstream application performance.
Strategic Antigen Design
The success of any antibody development project begins with the antigen. Our team leverages deep expertise in glycobiology to design and prepare high-purity GT1b antigens that are optimized for immunogenicity. We establish a robust and focused immune response by using techniques such as conjugation to carrier proteins or liposome presentation, which sets the foundation for the generation of high-affinity antibodies.
Flexible and Powerful Technology Platforms
We provide access to a suite of industry-leading technologies to create the ideal antibody for your needs. You can choose our well-established hybridoma platform for generating classic monoclonal antibodies. Alternatively, our advanced phage display technology can be utilized to screen vast libraries for antibodies with unique binding properties, offering a powerful route for discovering novel and highly specific binders against difficult carbohydrate targets.
Uncompromising Specificity Screening
We know that specificity is critical in ganglioside research. Every antibody candidate we develop is rigorously screened to ensure it binds specifically to GT1b. To eliminate the risk of misleading results, each potential hit is tested against a comprehensive panel of related gangliosides, including GM1, GD1a, and GD1b, ensuring that cross-reactivity is identified and eliminated early in the process.
Guaranteed Performance Through Rigorous Validation
An antibody is only valuable if it performs reliably in your experimental setup. We go beyond simple binding assays by offering comprehensive, application-specific validation. Whether your research calls for ELISA, immunohistochemistry (IHC), flow cytometry, or functional assays, we will validate the final antibody's performance in your chosen application, delivering a tool that is ready to generate clear and reproducible results from day one.
Engineering, Formatting, and Labeling (Optional)
Once optimal clones are selected, we offer a suite of engineering options. These include isotype switching, Fc domain modification, humanization, or conversion into recombinant antibody fragments such as Fab, scFv, or single-domain antibodies. Additionally, we can conjugate antibodies with HRP, biotin, or fluorophores upon request, ensuring immediate compatibility with your detection platforms.
Requirements and Collaboration Materials
- If you supply GT1b materials, please provide certificate/record of composition, solvent info, and handling conditions.
- If we prepare antigens, we will outline the route and QC steps before execution.
- If you have preferred counter-targets, we can incorporate them into the screening plan.
- Share intended applications to align selection criteria with downstream use.
Discuss Your GT1b Project
Ready-to-Use Anti-GT1b Antibody Products
In addition to our custom development services, Creative Biolabs offers a collection of ready-to-use anti-GT1b antibodies with verified specificity and performance. These off-the-shelf reagents are ideal for ELISA, IF, IHC, WB and other research applications targeting GT1b ganglioside. Each product is rigorously tested and accompanied by detailed datasheets to support your experimental workflows with confidence and convenience.
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Mouse Anti-GT1b Monoclonal Antibody (AGM-049YJ)(CAT#: AGM-049YJ)Online InquiryHost: MouseAntibody Isotype: IgG2bSpecies Reactivity: Human, Mouse, Rat, VertebRatesApplication: ELISA, IF, IHC, WB
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Mouse Anti-GT1b Monoclonal Antibody (CGYJ027)(CAT#: AGM-153YJ)Online InquiryHost: MouseAntibody Isotype: IgMSpecies Reactivity: HumanApplication: ELISA
Applications of Anti-GT1b Antibodies
Neurological Disease Modeling
- Induction of GT1b-mediated neuropathy in animal models
- Mapping nerve-specific GT1b distribution using immunohistochemistry
- Dissecting axon–glia interactions via antibody-targeted probes
Immunological Mechanism Studies
- Analyzing complement cascade activation
- Studying Fc-mediated effector functions (ADCC, CDC)
- Investigating GT1b antibody internalization and neuronal apoptosis
Diagnostic Biomarker Development
- Profiling serum anti-GT1b autoantibody levels in GBS, CIDP, or MFS
- Screening of ganglioside antibody panels using glycoarrays
Related Services You May Also Be Interested In
| Service | Description |
|---|---|
| Anti-Ganglioside Antibody Development | Comprehensive service for GM1, GD1a, GD3, GT1a, GT1b, GQ1b, etc. |
| Anti-Other Glycolipid Antibody Development | Custom service for sulfatide, galactocerebroside, globoside, and blood group antigens |
| Glycoarray Microarray Profiling | High-throughput screening of anti-glycan antibodies |
| Custom Anti-Glycan Antibody Development Service | Fully tailored anti-glycan antibody generation |
How to Start
- Share Your Goals: Indicate whether your priority is selectivity, kinetics, or application performance.
- Define Formats: Choose at least one antigen presentation format and identify preferred counter-targets.
- Confirm Assays & Deliverables: Select validation assays and output formats that match your study plan.
- Kick Off: We align milestones, reporting cadence, and decision gates to ensure efficient progress.
Ready to design a selective anti GT1b antibody or expand your panel of anti-ganglioside antibodies? Contact Creative Biolabs to discuss the most effective custom antibody service plan for your neurological autoimmunity studies.
FAQs
What are the antibodies for Guillain-Barré syndrome?
What antibody is associated with Miller-Fisher syndrome?
Miller-Fisher syndrome is most commonly linked with anti-GQ1b antibodies, though anti-GT1a and anti-GT1b antibodies have also been reported. We can generate or supply these antibodies with high specificity for your neuroimmunology research.
What kind of antigen format do you recommend for anti-GT1b antibody development?
We typically recommend GT1b conjugated to a carrier protein or embedded in liposomes, depending on the intended application. Our team will help select the best format to generate a focused and high-affinity immune response.
Can I provide my own GT1b antigen for the project?
Yes, you're welcome to supply your own GT1b materials. We'll coordinate with your team on composition, handling, and compatibility with our immunization or screening systems to ensure successful integration.