Custom Anti-MUC1 Glycan Antibody Service for Cancer & Immuno-oncology Research

Introduction: Unraveling the Significance of MUC1 in Cancer Biology

Mucin 1 (MUC1) is a heavily glycosylated transmembrane protein, predominantly expressed on the apical surface of epithelial cells. In normal physiology, MUC1 plays a role in forming protective mucous barriers. However, in cancer, this glycoprotein becomes aberrantly overexpressed and hypoglycosylated—resulting in the exposure of truncated carbohydrate moieties known as tumor-associated carbohydrate antigens (TACAs), such as Tn, STn, and TF antigens. These cancer-specific glycoforms, collectively referred to as MUC1-TACA, render MUC1 an attractive target for antibody development, cancer immunotherapy, and immunodiagnostics. Anti-MUC1 antibodies that recognize these glycan epitopes hold tremendous value for advancing our understanding of tumor biology and developing targeted interventions. At Creative Biolabs, we provide a cutting-edge custom anti-MUC1 glycan antibody service, designed to accelerate cancer and immuno-oncology research by generating highly specific and validated monoclonal or polyclonal antibodies against glycoengineered MUC1 antigens.

Fig.1 MUC1 structure.¹

Types of Anti-MUC1 Glycan Antibodies Offered

We offer a comprehensive panel of custom antibody development options, tailored to specific MUC1-associated glycan epitopes. These antibodies are designed for high specificity and low cross-reactivity to ensure precise tumor targeting. Each antibody is validated against synthetic glycopeptides or native tumor samples to ensure functionality in real-world assays.

One-Look Guide: Research Goal & Recommended Services

Service Overview: Anti-MUC1 Glycan Antibody Development

Our custom anti-MUC1 glycan antibody service focuses on delivering tailored solutions that meet diverse experimental needs, ranging from monoclonal antibody discovery to humanization and characterization. Whether you are studying the role of MUC1 in solid tumors or exploring MUC1 vaccine platforms, we ensure each antibody is designed to bind with high specificity to glycan motifs on cancer-associated MUC1.

Key Features:

• Generation of anti-MUC1 antibody against MUC1 glycans (Tn/STn/TF etc.)
• Use of glycopeptides, glycoproteins, or synthetic glycan conjugates as immunogens
• Multiple host species: mouse, rabbit, camelid, chicken, human
• Hybridoma, phage display, or single B cell cloning platforms
• Epitope mapping & glycan array screening
• Large-scale antibody production & purification
• Functional validation

Ready-to-Use Anti-MUC1 & Mucin Antibody Products

Need results now? Our ready-to-use anti-MUC1 antibodies help you stand up ELISA, IHC, IF, and flow assays quickly with reproducible lots. To compare mucin expression and reduce background, expand your panel with MUC2, MUC6, MUC16, and MUC5AC antibodies. Creative Biolabs supports multiple formats, buffers, and isotypes, and we tailor recommendations to your sample types and endpoints. All lots are QC-verified with application data and batch records available on request.

• Mouse Anti-MUC1 Monoclonal Antibody (CGYJ032)(CAT#: AGM-158YJ)

  Online Inquiry
  Host: Mouse

  Antibody Isotype: IgG1

  Species Reactivity: Human

  Application: WB, ELISA, FC, IHC, IHC-P, ICC/IF
• Rabbit Anti-MUC1 Monoclonal Antibody (AGM-317YJ)(CAT#: AGM-317YJ)

  Online Inquiry
  Host: Rabbit

  Antibody Isotype: IgG

  Species Reactivity: Human

  Application: IHC-P, IHC-Fr
• Human Anti-MUC1 Monoclonal Antibody (AGC-0425-QX476)(CAT#: AGC-0425-QX476)

  Online Inquiry
  Host: Human

  Antibody Isotype: IgG1

  Species Reactivity: Human

  Application: IHC, WB, FC, ELISA

Need Tailored Anti-MUC1 Antibodies

Application-Oriented Use Cases: Supporting Your Research Direction

Every lab has a different question about MUC1, and every question needs the right antibody. Below are common research scenarios we see, how our antibodies fit, and which Creative Biolabs services are the best match. If you recognize your project here, you're in the right place.

Tumor Glycosylation Profiling in Mucin-Rich Cancers

You're mapping how MUC1 glycosylation shifts across tumor types or grades (e.g., breast, pancreatic, ovarian, gastric). You need reagents that separate "normal" mucin from TACA signatures (Tn, sTn, TF, Lewis antigens). We provide glycoform-specific binders so you can localize, quantify, and compare MUC1 variants in FFPE tissues, cell lines, or model systems—without drowning in off-target noise.

Best-fit services:

• Anti-MUC1 Glycan Antibody Development
• Anti-Tn Antibody Development
• Anti-sTn Antibody Development
• Anti-T/TF Antibody Development

MUC1 Glycopeptide Vaccine Programs

You're advancing a MUC1 vaccine concept or evaluating immune readouts against MUC1-Tn/sTn. You need clean tools to track antigen presentation and antibody responses to specific glycans. Glycan-defined anti-MUC1 panels make it straightforward to confirm epitope exposure, monitor post-immunization titers, and compare adjuvant/formulation choices.

Best-fit services:

• Anti-Tn Antibody Development
• Anti-sTn Antibody Development

Glycan-Mediated Immune Evasion & Trafficking

Your project explores how sialyl-Lewis motifs shape leukocyte recruitment, immune escape, or metastatic behavior. You need reagents that read sLeᵃ/sLeˣ on the MUC1 scaffold with high specificity. We generate antibodies that distinguish sLeᵃ and sLeˣ on MUC1, enabling clean flow/IHC panels for trafficking and immunomodulation studies.

Best-fit services:

• Anti-sialyl-Lewis A Antibody Development
• Anti-sialyl-Lewis X Antibody Development

Liquid Biopsy & Circulating Glyco-Biomarkers

You're developing glycan-aware assays for serum/plasma—looking for circulating MUC1-TACA as research biomarkers or for longitudinal disease monitoring studies. High-affinity, glycoform-specific antibodies raise signal-to-noise in ELISA and multiplex formats, improving analytical sensitivity without sacrificing selectivity.

Best-fit services:

• Anti-Tn Antibody Development
• Anti-T/TF Antibody Development
• Anti-Lewis B Antibody Development
• Anti-Lewis Y Antibody Development

Cell Line & Tissue Panel Qualification

You're building or curating tumor panels and need reproducible markers to confirm MUC1 glyco-phenotypes across models. Our antibodies separate Leᵇ/Leʸ and core O-glycan states, so you can label models correctly and compare across labs or time points.

Best-fit services:

• Anti-Lewis B Antibody Development
• Anti-Lewis Y Antibody Development

Antibody Screening for ADC/CAR Concepts (Research-Stage)

You're scouting glycan-precise binders as research inputs for ADCs, bispecifics, or CAR constructs—prior to any translational step. We deliver binders that favor tumor-biased MUC1 glycoforms, helping you down-select candidates with better normal-tissue sparing in exploratory screens.

Best-fit services:

• Anti-sTn Antibody Development
• Anti-T/TF Antibody Development

Popular Services You May Need

At Creative Biolabs, we are committed to facilitating cancer research with precision antibody tools. Whether you're building a muc1 vaccine strategy or mapping tumor glycosylation patterns, our custom anti-MUC1 glycan antibody service provides the reliability and specificity your project demands. Contact our experts today to initiate your custom antibody development project!

FAQs

Reference:

1. Peng, Weiwei, et al. "Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing." Life Science Alliance 7.6 (2024). Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.26508/lsa.202302366

Supports

• Mucin