Dicer 1, Ribonuclease III; Dicer 1, Double-Stranded RNA-Specific Endoribonuclease; Dicer 1, Ribonuclease Type III; Helicase MOI; EC 3.1.26.3; Dicer; HERNA; Dicer1, Dcr-1 Homolog (Drosophila); Helicase With RNAse Motif; Helicase With RNase Motif; Endoribonuclease Dicer

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.