ACAN

Full Name

Aggrecan

Keywords

AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; SSOAOD; aggrecan core protein; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; large aggregating proteoglycan

Background

It is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration.