ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5; Aggrecanase-2; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2); A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11; ADAM-TS 11; ADAM-TS 5; ADAMTS-11; ADAM-TS5; ADAMTS-5

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.