DCN

Full Name

Decorin

Keywords

CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; decorin; bone proteoglycan II; dermatan sulphate proteoglycans II; proteoglycan core protein; small leucine-rich protein 1B

Background

It is a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication.