Deoxyribonuclease 1 Like 3; DNase Gamma; DNase I Homolog Protein DHP2; Deoxyribonuclease I-Like 3; Liver And Spleen DNase; DNase I-Like 3; LS-DNase; DNAS1L3; DHP2

This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.