EGFRvIII

Full Name

Epidermal growth factor receptor variant III

Keywords

Epidermal growth factor receptor; EGFR

Background

The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. The epidermal growth factor receptor (EGFR) exists in a deletion-mutant form, EGFRvIII, which has been identified by genetic and immunological means in a subset of gliomas and non-small cell lung carcinomas.