HNRNPA1

Hdp; HDP-1; Hnrpa1; hnRNP A1; hnrnp-A1; Heterogeneous Nuclear Ribonucleoprotein A1

Predicted to enable several functions, including RNA binding activity; identical protein binding activity; and single-stranded DNA binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome. Located in nucleus. Is active in synapse. Is expressed in several structures, including 1-cell stage embryo; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in HTLV-1-associated myelopathy/tropical spastic paraparesis; amyotrophic lateral sclerosis type 20; distal myopathy 3; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2).