HYAL2

Hyaluronoglucosaminidase 2

Enables several functions, including hyalurononglucosaminidase activity; transforming growth factor beta binding activity; and virus receptor activity. Contributes to transcription coactivator activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; hyaluronan catabolic process; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; multicellular organismal-level iron ion homeostasis; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface; membrane raft; and plasma membrane. Part of RNA polymerase II transcription regulator complex. Colocalizes with external side of plasma membrane. Is expressed in several structures, including alimentary system; heart; lateral plate mesoderm; respiratory system; and submandibular gland primordium. Orthologous to human HYAL2 (hyaluronidase 2).