KIN10

Full Name

SNF1 kinase homolog 10

Keywords

AKIN10; SNF1 kinase homolog 10; SNF1-RELATED PROTEIN KINASE; SNF1-RELATED PROTEIN KINASE 1.1; SNRK1.1; T4P13.22; T4P13_22; SNF1 kinase homolog 10; SNF1-related protein kinase catalytic subunit alpha KIN10

Background

It encodes a SNF1-related protein kinase that physically interacts with SCF subunit SKP1/ASK1 and 20S proteosome subunit PAD1. It can also interact with PRL1 DWD-containing protein. Based on in vitro degradation assays and cul4cs and prl1 mutants, there is evidence that AKIN10 is degraded in a proteasome-dependent manner, and that this depends on a CUL4-PRL1 E3 ligase.