O-Ac GD3

Full Name

O-acetylated GD3 Ganglioside

Keywords

O-acetylated GD3 Ganglioside; GD3 (OAc); GD3

Background

GD3 Synthase (GD3S, SIAT8, ST8SiaI, ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 1) is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce Ganglioside GD3 and Ganglioside GT3. Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is important for cell adhesion and growth of cultured malignant cells. GD3 Synthase is found in the Golgi apparatus and is a member of glycosyltransferase family 29. GD3 Synthase can downregulate MMP-9 promoter activity in response to TNFα by association with NFκB and activation protein-1 (AP-1) sites in the MMP-9 promoter. GD3 Synthase has an apoptotic effect on ECV304 cells through downregulation of Bcl-2 expression via dephosphorylation of AKT and CREB. O-acetylated GD3 Ganglioside (O-Ac GD3) is a cell surface molecule of some neural, neural crest and renal cells.