POLR1A

A190; RPA1; HLD27; RPO14; AFDCIN; RPA190; RPA194; RPO1-4; Rna Polymerase I Subunit A

The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis.