SGCG

Sarcoglycan Gamma; Sarcoglycan, Gamma (35kDa Dystrophin-Associated Glycoprotein); 35 KDa Dystrophin-Associated Glycoprotein; 35kD Dystrophin-Associated Glycoprotein; Gamma-SG; 35DAG; Limb Girdle Muscular Dystrophy 2C (Duchenne-Like Muscular Dystrophy, Autosomal Recessive); Maghrebian Myopathy (Autosomal Recessive); Gamma Sarcoglycan; Gamma-Sarcoglycan

This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).