Sialyl Tn

Full Name

Sialyl Tn antigen

Keywords

STn; Neu5Aca2-6GalNAca1-Ser/Thr; Sialosyl-Tn peptide; Sialosyl-Tn; NeuAcα2→ 6GalNAcα1→O-Ser/Thr

Background

Tn antigen refers to the monosaccharide structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond. Addition of an additional galactose monosaccharide creates a disaccharide antigen: the Thomsen-Friedenreich antigen (Gal(b1-3)GalNAc). The sialyl Tn antigen (STn antigen) is formed by elongation with sialic acid (Neu5Ac(a2-6)GalNAc) rather than galactose.