UDP-Glucose Pyrophosphorylase 2; UTP--Glucose-1-Phosphate Uridylyltransferase; UDP-Glucose Pyrophosphorylase 1; EC 2.7.7.9; UDPGP; UGP1; UTP--Glucose-1-Phosphate Uridylyltransferase 2; Uridyl Diphosphate Glucose Pyrophosphorylase-1; Uridyl Diphosphate Glucose Pyrophosphorylase 2; Testis Tissue Sperm-Binding Protein Li 58p; UTP-Glucose-1-Phosphate Uridyltransferase

The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene.