Wdr45b

Full Name

WD repeat domain 45B

Keywords

WIPI-3; Wdr45l; AA408735; D16Bwg0193e; 0610008N23Rik; WD repeat domain phosphoinositide-interacting protein 3; WD repeat-containing protein 45-like; WD repeat-containing protein 45B; WDR45-like protein; Wdr45 like

Background

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.