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Pinatuzumab vedotin (CAT#: TAB-899)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD22 Recombinant Antibody TAB-899 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant humanized antibody expressed in CHO binding to human CD22. Pinatuzumab vedotin is an antibody-drug conjugate (ADC) composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD22 while minimizing cytotoxic effects on hematologic cells that do not express CD22.
  • Target
  • CD22
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 1313706-14-7
  • Predicted N terminal
  • EVQLVESG
  • Molecular Weight
  • Approximately 150 kDa
  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Size
  • 1mg
  • Storage
  • At -20°C for one year.

BACKGROUND

  • Introduction
  • Pinatuzumab vedotin is an antibody-drug conjugate (ADC) composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD22 while minimizing cytotoxic effects on hematologic cells that do not express CD22.
  • Antigen Description
  • Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
  • Function
  • protein binding; sugar binding;
  • Synonyms
  • CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; SIGLEC-2; FLJ22814; MGC130020;

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