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Itolizumab (CAT#: TAB-247)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD6 Recombinant Antibody TAB-247 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to CD6. Itolizumab (INN, trade name Alzumab) is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. Itolizumab, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation. A double blind, placebo controlled, phase III treat –Plaq study of itolizumab successfully met the pre-specified primary end-point of significant improvement in PASI-75 (Psoriasis Area and Severity Index) score after 12 weeks of treatment in patients with moderate to severe psoriasis compared to placebo.
  • Target
  • CD6
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
  • CAS
  • 1116433-11-4
  • Specific Activity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1-kappa, anti-[Homo sapiens CD6 (Tp120, T12)],humanized monoclonal antibody;gamma1 heavy chain (1-449) [humanized VH (Homo sapiensIGHV3-21*08 (83.70%) -(IGHD)-IGHJ5*01) [8.8.12] (1-119) -Homosapiens IGHG1*01 (120-449)], (222-214")-disulfide with kappa lightchain (1"-214") [humanized V-KAPPA (Homo sapiens IGKV1-17*01(76.80%) -IGKJ2*01 F118>L, Q120>S) [6.3.9] (1"-107") -Homosapiens IGKC*01 (108"-214")]; (228-228"":231-231"")-bisdisulfidedimer
  • Predicted N terminal
  • H chain: EVQLVES; L chain: DIQMTQS
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
  • Function
  • scavenger receptor activity;
  • Synonyms
  • CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171;

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