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Ensituximab (CAT#: TAB-200)

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DESCRIPTION CATALOG # SIZE PRICE
Anti-Human MUC5AC Recombinant Antibody TAB-200 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to 5AC. Ensituximab is a chimeric monoclonal antibody used in the treatment of cancers.
  • Target
  • 5AC
  • Type
  • IgG1 - kappa
  • Immunogen
  • M1 mucin preparation from the fluid of an ovarian mucinous cyst.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
  • CAS
  • 1092658-06-4
  • Specific Activity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1-kappa, anti-[Homo sapiens MUC5AC (mucin5AC, mucin 5 subtypes A and C tracheobronchial/gastric)], chimericmonoclonal antibody;gamma1 heavy chain (1-443) [Mus musculus VH (IGHV2-3*01 -(IGHD)-IGHJ4*01) [8.7.7] (1-113) -Homo sapiens IGHG1*01 CH1L85.3>P, CH3 T81>M (114-443)], (216-213")-disulfide with kappalight chain (1"-213") [Mus musculus V-KAPPA (IGKV4-70*01 -IGKJ1*01) [5.3.9] (1"-106") -Homo sapiens IGKC*01 (107"-213")];(222-222"":225-225"")-bisdisulfide dimer
  • Predicted N terminal
  • H chain: QVQLKES; L chain: QVVLTQS
  • Molecular Weight
  • 142800
  • Purity
  • >95.0% as determined by analysis by RP-HPLC.
  • Size
  • 1mg
  • Storage
  • At -20°C for one year.

BACKGROUND

  • Antigen Description
  • Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen.
  • Function
  • extracellular matrix structural constituent;
  • Synonyms
  • MUC5AC; mucin 5AC, oligomeric mucus/gel-forming; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin-5AC; MUC5; gastric mucin; tracheobronchial mucin; major airway glycoprotein; lewis B blood group antigen; mucin-5 subtype AC, tracheobronchial; mucin 5AC, oligomeric mucus/gel-forming pseudogene; TBM; leB;

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