Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMonitoring of immune responses caused by biotherapeutic drug treatment is a regulatory requirement during preclinical development through to clinical trials. ADA is one of the most common causes of the efficacy loss of some drugs. Moreover, the appearance of ADA can trigger an allergic reaction. However, optimization and validation of assays for anti-drug antibodies (ADA) are challenging due to the excess of human antibodies in serum and the relatively low immune response. With the development of ADA assays, various methods have been used in actual applications. Among both of them, anti-idiotypic antibodies were widely applied as a positive control to measure the concentration of specific ADA conveniently and sensitively combined with quantitative methods such as sandwich ELISA.
Fig.1 Factors influencing ADA detection in immunoassays.1
There are three commonly used methods in recent ADA assays: ELISA, cell-based assays, and label-free biosensors. As a mature method, ELISA is the simplest approach which also takes sensitivity into account. As a positive control, anti-idiotypic antibodies have strong specificity and high sensitivity, which provides a general approach to detect various target antibodies by ELISA. Therefore, the development of specific anti-idiotypic antibodies is necessary to expand the range of ELISA applications in ADA assay.
Fig.2 ELISA for ADA detection.2
Fortunately, recombinant monoclonal antibodies against biotherapeutics can be created using sophisticated antibody libraries and well-established phage display technology. Moreover, modified hybridomas technology also can be used to prepare anti-idiotypic antibodies.
Creative Biolabs provides commercial products and customized one-stop services for anti-idiotypic antibody development. For more details please feel free to contact us. You can also click here to see more custom Anti-Idiotypic Antibodies Production Services from Creative Biolabs to meet your specific requirements.
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