Creative Biolabs is constantly devoted to innovating the way of raising good antibodies for assay development, drug discovery and many other applications. With rich experience in this field, we are proud to introduce our world-class anti-membrane protein antibody discovery service using mouse hybridomas to worldwide researchers.
Hybridoma technology has been the most classic & dominant approach and a milestone for the monoclonal antibody discovery since 1970s. It is widely applied in rodents to raise mAbs against many different target molecules after immunization. On the other hand, as the most popular lab animal in biology and antibody development, mouse has many appealing properties. First of all, mice and humans share about 97.5% of their genes and produce similar antibody isotypes with human. Moreover, it is by far the best-characterized species, and very easily manipulated. Mouse is also well-developed to conduct gene modification and generate special transgenic strains. Taking advantages of these features, Creative Biolabs has integrated diverse transgenic mouse strains for antibody discovery to fulfill various demands. For example, we bring out a Speed™ anti-membrane protein antibody development platform. The gene-modified mice used on this platform are more sensitive to foreign immunogens and can be fast immunized in less than 20 days. We also provide several humanized mouse strains, which can be utilized to produce fully human antibodies bypassing the tedious humanization process in vitro.
Features of our Anti-Membrane Protein Antibody Discovery Using Mouse Hybridoma:
Our rich experience in mice immunization makes it possible to raise adequate immune response and generate large amount of hybridoma clones. We frequently obtain over 50-200 clones per fusion, providing the solid basis to isolate high-affinity, high-specificity antibodies.
Creative Biolabs has well-established membrane protein immunogen preparation platform, specifically designed for all kinds of membrane antigens. A variety of expression systems, stabilization format, modifications can be applied to tailor most appreciate immunogen. In addition, we also provide a highly effective adjuvant to ensure strong immunity in vivo.
All mouse strains especially gene-modified ones can be well incorporated with hybridoma technology. We offer flexible options for each specific case according to custom requirements.
Creative Biolabs presents comprehensive service package from the initial experimental design to the antibody sequencing and production. We are happy to tailor customized workflow to best address clients’ needs.
Creative Biolabs has long been dedicated to generating superior-class antibodies against various membrane proteins. Our experienced scientists are more than glad to share our forefront platforms and resources to assist your specific project. Please feel free to contact us for more details.