Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAs one of the world's leading providers of antibody discovery services, Creative Biolabs has been constantly dedicated to assisting our customers with their diverse development projects. Particularly, we offer professional anti-membrane protein antibody discovery services using mouse phage display immune library method.
Membrane proteins, such as GPCRs and ion channels, participate in diverse key cellular functions. Many diseases, e.g. cancers, autoimmune diseases, infection diseases, accompanied by the dysfunction of membrane proteins. Discovery of anti-membrane protein antibody takes a crucial part in diverse therapeutic and diagnostics research. Hybridoma technology represents a classic and well-developed approach, but the limitations in fusion efficacy and host species often pose as a big challenge. In contrast, phage display technology provides a promising alternative to generate high-specific, high-affinity antibody binders.
The unique characteristic of phenotype-genotype linkage makes phage display a robust and straightforward strategy for antibody discovery. Antibody phage display libraries derived from immunized mice is proved as an attractive approach in this regard. Creative Biolabs provides the world first-class phage display library construction services for years. Based on this platform, a large number of promising clones have been identified, some of which have already entered clinical stages. Besides, the small size, high reproduction rate of mice and easiness of maintenance and handling make them the top popular mammalian animal models in laboratory.
Advantages of anti-membrane protein antibodies discovery using mouse immune library:
Mice and humans share about 97.5% of their working DNA. According to whole genome sequencing analysis, it is revealed that there are only 21 human genes that do not have a direct counterpart in mouse genome, and only 14 genes are unique to mice that are not found in humans.
We have integrated multiple transgenic mouse strains, which can be used for different research purpose. For example, on our Speed™ anti-membrane protein antibody development platform, we developed unique gene-modified mice which can raise significant immune responses in only 20-day period. We also have a Magic™ humanized transgenic mice platform, on which 100% human antibodies can be generated.
Creative Biolabs has well-established membrane protein immunogen preparation platform, specifically designed for membrane antigens. A variety of expression systems, stabilization format, modifications can be applied to tailor most appreciate immunogen. In addition, we also provide a highly effective adjuvant to ensure strong immunity in vivo.
Creative Biolabs has been long dedicated to anti-membrane protein antibody development using various approaches (e.g. hybridoma, B cell sorting, etc.). We tailor and execute custom solutions to address every specific requirement. With numerous successful cases in anti-ion channel antibody production, anti-GPCR antibody production, and anti-transporter antibody production, our scientists are happy to work with you step by step to ensure the most satisfactory outcome. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
