Anti-Membrane Protein Antibody Discovery Using Rat Hybridoma

Creative Biolabs is a world-leading research institute and service provider that constantly focuses on antibody discovery and development for therapeutic/diagnostic applications. Equipped with extensive experience and advanced technologies, now we offer first-class anti-membrane protein antibody discovery service using rat hybridomas.

Membrane proteins, e.g. G protein-coupled receptors (GPCRs) and ion channels, are currently the most important class of therapeutic targets for diverse diseases. Monoclonal antibodies directed against membrane proteins now serve as powerful weapons for therapeutic, diagnostic, and research purposes. As is known, hybridoma is a most classic, reliable and widely used approach for antibody discoveries. Over years, Creative Biolabs has successfully developed multiple anti-membrane protein antibodies and gained valuable experience for anti-membrane protein antibody discovery using rat hybridoma.

As one of the most popular lab animals, rat takes an essential part in many biological experiments. Comparing with its rodent brother mice, rats are larger murine which means greater lymphocyte yield and reduced antigen requirement. Moreover, analogously speaking, rats also generate more abundant antibody repertoire (IgA, IgD, IgE, IgG and IgM antibody isotypes) that can recognize broader range of human & mouse antigens. Hence, rat mAbs can be a promising choice or complement for researchers to develop antibodies against challenging targets.

Features of Anti-Membrane Protein Antibody Discovery Using Rat Hybridoma:

High specificity and high affinity (picomolar has been obtained for some cases)
Multiple antigen formats
With the help of our all-around membrane protein immunogen preparation platform, multiple formats of membrane proteins (including liposomes, polymers, nanodiscs, designed peptides, DNA immunization, whole cell presentation, etc.) can be utilized for immunization and antibody selection.
Better immune properties
The rat immune system is capable of mounting potent immune response to mouse/human antigens, while mouse can be sometimes problematic due to high tolerance to many syngeneic antigens. Rat antibodies also pair better than mouse in sandwich assays.
Ability to recognize subtle changes such as post-translational modifications
Greater lymphocyte yields and ability to generate larger panels of bioactive antibodies compared to mice
Skillful teams and professional support: our scientific staff has accumulated extensive experience in tailoring rat hybridoma antibodies from hundreds of cases. A long list of success records can be tracked for whom we generated superior antibodies for research/therapeutic use.

As a well-recognized antibody services provider, Creative Biolabs is professional in raising monoclonal antibodies against various membrane proteins. We offer customized service package in a one-stop pipeline ranging from immunogen preparation to downstream antibody sequencing and production to fulfill your needs. With our Ph.D. level science team and years of experience, plenty of Anti-Ion Channel Antibody, Anti-GPCR Antibody, and Anti-Transporter Antibody have been successfully obtained. We are more than happy to share our experience and help our customers with their projects. Please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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