Interfering Nucleic Acid Discovery Services for Infectious Disease Research
In infectious disease research, the development of interfering nucleic acid drugs is progressing rapidly. These drugs show great potential for treating various infectious diseases, including viral and bacterial diseases, by specifically targeting pathogen genes or modulating the host's immune response. Research is particularly active in the area of viral infections, such as HIV and hepatitis B virus. However, the delivery and stability of these drugs remain major challenges in research and application. Creative Biolabs is actively supporting and assisting clients in exploring and developing the enormous potential of interfering nucleic acid drugs in the treatment of infectious diseases.
Fig.1 Mechanism of RNA interference as a treatment strategy in chronic hepatitis B.1
Advantages of Interfering Nucleic Acid Drugs
Interfering nucleic acid drugs are a class of drugs that use nucleic acid molecules for treatment. They achieve therapeutic purposes by binding to specific sequences or through interference mechanisms to degrade or inhibit the expression of specific genes. Compared to other types of drug development, interfering nucleic acid drugs have many advantages.
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Precision targeting: By specifically targeting the genetic information of pathogens or gene expression of host cells, interfering nucleic acid drugs can precisely intervene in the disease process.
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Rapid development: Compared to traditional drugs, the development cycle of interfering nucleic acid drugs is usually shorter, enabling a quick response to emerging disease challenges.
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Low risk of resistance: Due to their unique mechanism of action, interfering nucleic acid drugs are less likely to cause pathogen resistance.
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Lower side effects: Compared to many traditional drugs, interfering nucleic acid drugs have less impact on host cells while targeting treatment, hence usually have lower side effects.
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Driven by technological advances: With the development of biotechnology and molecular biology, the research and production technology of interfering nucleic acid drugs continue to advance, improving their efficacy and safety.
Fig.2 Overview of miRNA biogenesis and functions and siRNA mechanisms of action.2
Interfering Nucleic Acid Screening and Development Services at Creative Biolabs
Creative Biolabs integrates a platform for drug discovery, production, and preclinical research. Using a rigorous scientific attitude and advanced equipment, it offers a range of advanced interfering nucleic acid screening and development services aimed at supporting drug research in the field of infectious diseases.
In addition, we also offer:
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Nucleic acid drug synthesis and modification services: Providing one-stop services from monomer synthesis to modification, including nucleotide monomer synthesis, oligonucleotide synthesis, delivery system synthesis, and various chemical modifications such as sugar modification, base modification, backbone modification.
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Biological activity evaluation services: Including target mRNA/protein level reduction assessment, cell phenotype, and functional interference evaluation.
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Off-target effect assessment services: Using databases to find potential off-target mRNAs and proteins, and overall analysis of off-target phenomena.
Service advantages
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Flexible synthesis scale: Capable of providing synthesis quantities from mg to kg level, adapting to the needs from basic research to large-scale production.
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High purity, low toxicity: Enhancing product purity (HPLC purity can reach over 90%) and reducing cell toxicity through optimized purification processes.
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Diverse chemical modifications and fluorescent labeling: Meeting customized needs of clients, enhancing the therapeutic effect and delivery efficiency of drugs.
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Customized services: Including customized quality control testing and a senior technical support team, ensuring professional and smooth services.
Creative Biolabs provides comprehensive and efficient interfering nucleic acid services, covering everything from advanced nucleic acid synthesis, precise chemical modifications to in-depth biological activity evaluation. Our one-stop solution aims to bring breakthrough progress to your research and development projects. If you are seeking high-quality, reliable interfering nucleic acid research and development services, please feel free to contact us.
References:
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Hui, RW.; et al. RNA interference as a novel treatment strategy for chronic hepatitis B infection. Clinical and Molecular Hepatology. 2022, 28(3):408-424.
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Traber, GM.; Yu, AM. RNAi-based therapeutics and novel RNA bioengineering technologies. Journal of Pharmacology and Experimental Therapeutics. 2023, 384(1):133-154.
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For Research Use Only. We do not provide direct services or products for patients.
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