As an industrial leader specialized in custom services, Creative Biolabs has developed an advanced anti-bacteria biomolecular discovery system to provide various excellent biomolecular identification service for different purposes. Through our high-throughput system, we can provide the best service of anti-mycoplasma antibody development, mycoplasma-specific binding peptide identification and epitope mapping of immunogenic proteins. Clients can accelerate their research with reducing project costs and timelines.
Mycoplasma belongs to the class Mollicutes and are distinguished from other bacteria by their total lack of a cell wall. They have the smallest genome (580–1,358 kb) of all self-replicating bacteria, the GC content of the genome is very low (24–40%), and they use the opal stop codon UGA to encode tryptophan. Membrane surface proteins play a fundamental role in the pathogenesis of mycoplasmas; in particular, the attachment of mycoplasmas to host cells is mediated by cytoadhesins. Mycoplasmas affect the immune system by inducing either suppression or polyclonal stimulation of B and T lymphocytes, triggering the expression of up- and down-regulating cytokines, and increasing the cytotoxicity of macrophages, natural killer cells, and T cells. There are many different species. Several species are pathogenic in humans, including Mycoplasma pneumoniae, which is a human respiratory tract pathogen commonly causing tracheobronchitis, atypical pneumonia, and pharyngitis, and Mycoplasma genitalium, which is believed to be involved in pelvic inflammatory diseases. Several species are pathogenic in ruminants, such as Mycoplasma agalactiae. Mycoplasma agalactiae is the etiological agent of contagious agalactia, a disease affecting sheep, goats, and other small ruminants. It primarily affects the mammary glands, joints, and eyes, causing various clinical manifestations. In most cases, infections result in a rapid drop in milk production. The disease causes severe economic losses in areas where the economy is largely based on shepherding.
Creative Biolabs has established a high-throughput anti-bacteria biomolecular discovery system. Our seasoned scientists have developed several strategies for anti-mycoplasma antibody discovery. Diverse species can be used as targets, including but not limited to Mycoplasma Pneumoniae, Mycoplasma Genitalium, Mycoplasma agalactiae, Mycoplasma hyopneumoniae, Mycoplasma arginine.
An important goal in medicine is the development of methods for cell-specific targeting of therapeutic molecules to pathogens or pathogen-infected cell. New therapeutic treatments for pathogen-infected cells will be continually required, especially considering the threats from biological warfare agents and emerging infectious diseases. One impediment to the development of new therapies for infectious diseases concerns the need to target specific cells, tissues or organs in which the pathogen resides. Cell-specific delivery of the therapeutic is expected to increase the efficacy of the drug while decreasing its side effects. In addition, specific delivery will reduce the amounts of drug required, thereby reducing the probability of developing drug resistance. Creative Biolabs has accumulated extensive experience in the identification of mycoplasma-specific binding peptide using superior methodologies and technologies.
Phage display techniques have been widely employed to map the epitope structures which served as the basis for developing molecular vaccines. The epitope identification of immunogenic proteins of pathogens is very important for the development of diagnostic tools and vaccines. In the field of applying phage display technology for epitope mapping, Creative Biolabs has rich experience and we can offer high-quality customized services by adjusting protocols to meet every unique requirement.
Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs is pleased to share our cutting-edge technology and extensive expertise in anti-mycoplasma antibody discovery, mycoplasma-specific binding peptide identification and epitope mapping of immunogenic proteins. We offer turn-key or ala carte services customized to our client’s needs. Please contact us for more information and a detailed quote.
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