Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAquaporins (AQP) are a family of intrinsic membrane proteins that function as water-selective channels controlling transportation of water in and out of cells. Besides, in some cases, they also function as transporters of small neutral solutes, glycerin, urea, etc. More than 10 isoforms hav been identified from various tissues. Structural analyses of aquaporins amino acid sequence has shown 6 highly conserved hydrophobic bilayer spanning domains that consist of 18-25 amino acids each, a 2-fold repeat in the primary structure, and two conserved asn-pro-ala (NPA) motifs. These proteins are expressed in tissue- and cell-specific manners, and are closely related to the specific functions of tissues and cells. Studies have revealed that aquaporins expressed in specific tissues and cells are associated with reabsorption of water in the kidney, cerebrospinal fluid secretion and reabsorption, production of pulmonary secretions, aqueous humor secretion and reabsorption as well as multiple other physiologic processes.
Here shows part of aquaporin family in humans including AQP0 found in the lens; AQP1 found in the blood vessels, kidney proximal tubules, eye, and ear; AQP2 found in the kidney collecting ducts; AQP3 found in the kidney collecting ducts, epidermis, urinary, respiratory, and digestive tracts, etc. The diverse and characteristic distribution of aquaporins in the body suggests their multiple physiologic functions.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
