Introduction of ASIC3
ASIC3, also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1), is encoded by ASIC3 gene. It belongs to the ASIC/ENaC superfamily and is predominantly expressed in dorsal root ganglia neurons, especially in nociceptive sensory neurons. Recent studies show that ASIC3 plays an important role in pain perception, especially in high-intensity pain stimulation and acid-induced hyperalgesia. Meanwhile, ASIC3 has been regarded as a potential therapeutic strategy for arthritis.
|Basic Information of ASIC3|
|Protein Name||Acid-sensing ion channel 3|
|Aliases||ACCN3, SLNAC1, TNAC1|
|Organism||Homo sapiens (Human)|
Function of ASIC3 Membrane Protein
Acid-sensing ion channel 3 (ASIC3) has two hydrophobic transmembrane domains (TM1 and TM2), short intracellular N-and C- termini, and a large cysteine-rich extracellular loop. ASIC3 is extracellular proton-gated cation channel that has been implicated in multiple physiological and pathological processes. ASIC3 has also been shown to play an inhibitory role in synovial proliferation and subsequent accumulation of inflammatory mediators, indicative of a protective effect in joints. Researches reveal that acid sensing ion channel 3 (ASIC3) is the most sensitive to extracellular pH and has the characteristic ability to generate a biphasic current. Acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) has been proposed to be involved in the pathophysiology of hypertension.
Fig.1 Model of the interaction of NHERF-1 with ASIC3. (Deval, 2006)
Application of ASIC3 Membrane Protein in Literature
This article analyzes the effect of several compounds on the ASIC-mediated currents and acid-induced nocifensive behavior. These results show that small molecule drug can be designed to target ASIC3 channels to treat pain-related diseases.
Authors assess the expression levels of nerve growth factor (NGF) and acid-sensing ion channel 3 (ASIC3) in prostatic tissue of experimental rats with type Ⅲ prostatitis. The data illustrate that NGF and ASIC3 are highly expressed in the prostate with EAP.
Authors in this group reveal that ASIC3 expression is increased in the hippocampus of pilocarpine induced seizure rats, as well as in hippocampal neuronal cultures undergoing epileptiform discharge elicited by Mg2+-free media and find ASIC3 agonists could be used to seizure treatment.
Authors analyze the genetic polymorphisms of the ASIC3 and TRPV1 genes and blood pressure (BP) variations in Taiwanese population. These results indicate that the interaction between ASIC3 and TRPV1 is involved in BP regulation.
This article reveals the interaction relationship between acid-sensing ion channels (ASIC3) and of ATP-sensitive P2X receptors (P2X3Rs) in sensory neurons. The receptor sub-units are tightly associate with each other to form a protein complex, mediating unidirectional inhibition.
ASIC3 Preparation Options
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