Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe ATP-binding cassette subfamily B (ABCB) family belongs to the transport system superfamily. It is composed of four full transporters and two half transporters. ABCB1, also known as P-glycoprotein, is a well-characterized ABC reporter in terms of its tissue distribution, functions in cancer cells, and clinical significance. ABCB4 is localized at the canalicular membrane of hepatocytes and mediates the translocation of phosphatidylcholine into bile. Genetic defects of ABCB4 may cause progressive familial intrahepatic cholestasis type 3 (PFIC3) and other cholestatic or cholelithiasis diseases in heterozygous adults. ABCB5 has been shown to serve as a clinically relevant multidrug resistance mediator in human malignant melanoma, colorectal cancer, and hepatocellular carcinoma. ABCB6 is a mitochondrial transporter that regulates porphyrin biosynthesis and it may play a role in cell growth and proliferation by targeting the cell cycle. Mutations in ABCB6 cause diseases like ocular coloboma. ABCB11 is the bile salt export pump (BSEP), the major transporter responsible for biliary bile acid secretion, which expression is restricted to hepatocytes.
Here, we give an introduction to the following ABCB members focusing on our current knowledge on their expression, trafficking, function, and recent advances in fundamental research with promising therapeutic perspectives.
With the development of new solutions and strategies for membrane protein solubilization and stabilization, significant progress has been made in the field of in vitro membrane protein characterization in recent years. At Creative Biolabs, our detergent screening platform can help you choose the right detergents. Besides, alternatives to detergents such as liposomes, nanodiscs, lipoparticles, and polymers are also available. These new approaches employ either a detergent-assisted or detergent-free method, thus reducing the denaturing effects of detergents and maximally maintaining the functional activity. Different formats of membrane protein products are suitable for different applications. For detailed information, please see Magic™ membrane protein production platform.
Meanwhile, as an undisputed pioneer in the antibody discovery and engineering field, Creative Biolabs proudly introduces our professional service of anti-membrane protein antibody discovery with our diverse technologies. Please see Magic™ membrane protein antibody discovery for more information. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in our services, just contact us and discuss your requirements.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
