This product is a Toledo B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-321-huIgH296-SpCas9-RS-1 ) genome editor.
| Host Cell | Toledo |
| Target | 14-3-3 Pan |
| Insert Clone | LG.3A10 |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | DOX |
| Particle Size | 10-1000 |
| Charge (mv) | <-1 |
| Total Atom Count | ~30,000,000 |
| Surface Atoms (%) | ~1.7 |
| Specific Surface Area (m2/g) | ~5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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