This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Tumor-homingpeptide tLyp-1/NRP-1) delivery system and CRISPR-based (AAVS1-tracr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | 5T4 |
| Insert Clone | H8 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | <2500 |
| Charge (mv) | −11 to -345 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer |
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