This product is a Farage B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-Brefeldin A ) genome editor.
| Host Cell | Farage |
| Target | ABCC1 |
| Insert Clone | CRT1.773a |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | <2500 |
| Charge (mv) | 10 to 100 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Prostate cancer; Lung cancer; Colon cancer; Cervical cancer |
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