This product is a Toledo B cell engineering tool based on the Dendrimers (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-317-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | Toledo |
| Target | ABCC1 |
| Insert Clone | CRT1.786a |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | DOX |
| Particle Size | 10-500 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Prostate cancer; Lung cancer; Colon cancer; Cervical cancer |
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