Creative Biolabs specializes in genetic designs and B cell engineering with high standards for anti-autoimmune diseases antibody delivery.
Autoimmune diseases occur in millions of people every year, which are caused by unnecessary immune responses to autoimmune antigens. Autoimmune diseases include many types, such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, and type 1 diabetes mellitus. In recent years, a variety of drugs have been discovered and used to treat autoimmune disease, including anti-metabolite drugs, such as purine synthesis inhibitor azathioprine, immuno-suppressive drugs, such as cytokine gene transcription inhibitor ciclosporin, and novel biologic drugs, such as human monoclonal antibody against B-cell activating factor belimumab.
Fig.1 Adoptively Transferred Engineered B cells Can Undergo Antigen-induced Activation.1,2
B cells are natural secretory cells of antibodies and cytokines, and have a great variety of immune effector functions, making them the ideal gene therapy target cells to secret therapeutic proteins associated with genetic diseases, infectious diseases, cancers, and autoimmune disorders. With the further development of genome editing and delivery techniques, genetic engineering of B cells is emerging as a novel while rapidly growing field for disease treatment and prevention.
Built on our advanced, high-throughput platforms and world-renowned expertise in the immune-oncology area, Creative Biolabs offers comprehensive B Cell engineering service for anti-autoimmune diseases antibody delivery to help accelerate your autoimmune disease project process.
Fig.3 The main workflow for the one-stop B cell engineering service. (Creative Biolabs)
For more details about our strategies for engineering B cells portfolio services, please don't hesitate to contact us for more information.