Respiratory tract-draining lymph nodes are the main site of influenza-induced B cell activation. The activation of B cells leads to the induction of antibody-secreting cells (ASCs) producing class-switched, protective antibodies. Germinal center (GC) -derived plasma cells are generated after strong influenza-specific antibody responses are produced by extrafollicular (EF) B cells well. After rapid and strong B cell proliferation, EF cells differentiate into short-lived plasmablasts that secrete IgM, IgA and IgG. Creative Biolabs provides the B cell engineering service to manufacture antibodies to defend against the invasion of influenza virus.
Creative Biolabs' B cell engineering service for anti-influenza virus antibody delivery involves both innate-like and conventional B cells, which provides early and later immune protection. Engineering B cells with precise genome editing techniques to adapt to the ever-changing influenza virus will enhance overall protection.
Fig.1 B cell engineering service for anti-influenza virus antibody delivery. (Creative Biolabs)
Paper Title: Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus
Therapeutic Antibody: Anti- Influenza Virus Antibody
Journal: Cell Systems
IF: 11.091
Published: 2020
Background: The adaptive immune system accommodates essentially any antigen due to the antibody repertoire possessing various diversity. However, this diversity allows the influenza virus to impose complex immunodominance hierarchies. This research developed a computational model. This computational mode is affinity maturation, which can map the patterns of immunodominance.
Results: The novel computational model has complex patterns in antibody immunogenicity, which can be rationally defined and then manipulated to elicit engineered immunity.
|
|
B Cell Engineering Service for Anti-COVID-19 Antibody Delivery |
| Creative Biolabs provides the B cell engineering service to manufacture antibodies to defend against the invasion of COVID-19 virus. Please click to know more. | |
|
|
B Cell Engineering Service for Anti-HIV Antibody Delivery |
| Creative Biolabs provides the B cell engineering service to manufacture antibodies to defend against the invasion of HIV virus. Please click to know more. | |
|
|
B Cell Engineering Service for Anti-RSV Antibody Delivery |
| Creative Biolabs provides B cell engineering services by different genome editing methods to manufacture antibodies to defend against the invasion of RSV. Please click to know more. | |
|
|
B Cell Engineering Service for Anti-EBV Antibody Delivery |
| Creative Biolabs provides B cell engineering services to manufacture antibodies by to defend against the invasion of EVB. Please click to know more. |
Q1. How does B cell regulate the immune response?
A: Except for antibodies, B cells also generate cytokines with which they can regulate the immune response, and they can act as APCs to CD4 and CD8 T cells.
Q2. What is the epitope of neutralizing antibodies targeting influenza viruses?
A: Broadly neutralizing antibodies targeting influenza viruses largely bind conserved epitopes found within the receptor binding site (RBS), lateral patch, and stalk domain of the viral surface protein hemagglutinin (HA).
With a team of scientists who come from different research backgrounds, Creative Biolabs guides you all the way from project inception to high-quality results. For more B cell engineering information, please visit the unit of B Cell Engineering Service for Therapeutic Antibody Delivery. If you have interest, please do not hesitate to contact us.
